Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/52840
Title: Acute Muscle Mass Loss Predicts Long-Term Fatigue, Myalgia, and Health Care Costs in COVID-19 Survivors
Authors: GIL, SauloOLIVEIRA JUNIOR, Gersiel Nascimento deSARTI, Flavia MoriFILHO, Wilson JacobLONGOBARDI, IgorTURRI, Jose Antonio OrellanaSHINJO, Samuel KatsuyukiFERRIOLLI, Eduardo-SILVA, Thiago Junqueira AvelinoBUSSE, Alexandre LeopoldGUALANO, BrunoROSCHEL, Hamilton
Citation: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, v.24, n.1, p.10-16, 2023
Abstract: Objective: We examined the impact of loss of skeletal muscle mass in post-acute sequelae of SARS-CoV-2 infection, hospital readmission rate, self-perception of health, and health care costs in a cohort of COVID-19 survivors.Design: Prospective observational study.Setting and Participants: Tertiary Clinical Hospital. Eighty COVID-19 survivors age 59 +/- 14 years were prospectively assessed.Methods: Handgrip strength and vastus lateralis muscle cross-sectional area were evaluated at hospital admission, discharge, and 6 months after discharge. Post-acute sequelae of SARS-CoV-2 were evaluated 6 months after discharge (main outcome). Also, health care costs, hospital readmission rate, and self -perception of health were evaluated 2 and 6 months after hospital discharge. To examine whether the magnitude of muscle mass loss impacts the outcomes, we ranked patients according to relative vastus lateralis muscle cross-sectional area reduction during hospital stay into either ""high muscle loss"" (-18 +/- 11%) or ""low muscle loss"" (-4 +/- 2%) group, based on median values. Results: High muscle loss group showed greater prevalence of fatigue (76% vs 46%, P =.0337) and myalgia (66% vs 36%, P = .0388), and lower muscle mass (-8% vs 3%, P < .0001) than low muscle loss group 6 months after discharge. No between-group difference was observed for hospital readmission and self -perceived health (P > .05). High muscle loss group demonstrated greater total COVID-19-related health care costs 2 ($77,283.87 vs. $3057.14, P = .0223, respectively) and 6 months ($90,001.35 vs $12, 913.27, P = .0210, respectively) after discharge vs low muscle loss group. Muscle mass loss was shown to be a predictor of total COVID-19-related health care costs at 2 (adjusted f3 = $10, 070.81, P < .0001) and 6 months after discharge (adjusted f3 = $9885.63, P < .0001). Conclusions and Implications: COVID-19 survivors experiencing high muscle mass loss during hospital stay fail to fully recover muscle health. In addition, greater muscle loss was associated with a higher frequency of post-acute sequelae of SARS-CoV-2 and greater total COVID-19-related health care costs 2 and 6 months after discharge. Altogether, these data suggest that the loss of muscle mass resulting from COVID-19 hospitalization may incur in an economical burden to health care systems.(c) 2022 AMDA -The Society for Post-Acute and Long-Term Care Medicine.
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Artigos e Materiais de Revistas Científicas - COVID-19
COVID-19

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - LIM/66
LIM/66 - Laboratório de Investigação Médica em Envelhecimento

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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