Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/52873
Title: Association between objective sleep measures and cognitive performance: a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) study
Authors: SUEMOTO, Claudia K.SANTOS, Ronaldo B.GIATTI, SorayaAIELO, Aline N.SILVA, Wagner A.PARISE, Barbara K.CUNHA, Lorenna F.SOUZA, Silvana P.GRIEP, Rosane H.BRUNONI, Andre R.LOTUFO, Paulo A.BENSENOR, Isabela M.DRAGER, Luciano F.
Citation: JOURNAL OF SLEEP RESEARCH, v.32, n.2, article ID e13659, 10p, 2023
Abstract: Sleep disturbances often co-exist, which challenges our understanding of their potential impact on cognition. We explored the cross-sectional associations of insomnia and objective measures of sleep with cognitive performance in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) study stratified by middle-aged and older adults. Participants aged >= 55 years underwent cognitive evaluations, polygraphy for 1 night, and actigraphy for 7 days. Insomnia was evaluated using the Clinical Interview Scheduled Revised. Obstructive sleep apnea (OSA) and short sleep duration (SSD) were defined by an apnea-hypopnea index (AHI) of >= 15 events/h and <6 h/ night, respectively. In 703 participants (mean [SD] age 62 [6] years, 44% men), cognition was evaluated using a 10-word list, verbal fluency, and trail-making tests. The frequencies of insomnia, SSD, and OSA were 11%, 24%, and 33%, respectively. In all, 4% had comorbid OSA and insomnia, and 11% had both OSA and SSD. Higher wake after sleep onset (beta = -0.004, 95% confidence interval [CI] -0.008, -0.001) and the number of awakenings (beta = -0.006, 95% CI -0.012, -0.001) were associated with worse verbal fluency performance. Compared to those without insomnia, older participants with insomnia had worse global performance (beta = -0.354, 95% CI -0.671, -0.038). Insomnia was an effect modifier in the associations between AHI and executive function performance (p for the interaction between insomnia and AHI = 0.004) and between oxygen saturation <90% and memory performance (p for the interaction between insomnia and oxygen saturation = 0.02). Although some associations between sleep measures and cognition were significant, they should be considered with caution due to the large sample size and multiple testing performed in this study.
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