Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/5398
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BETTEGOWDA, Chetan | - |
dc.contributor.author | SAUSEN, Mark | - |
dc.contributor.author | LEARY, Rebecca J. | - |
dc.contributor.author | KINDE, Isaac | - |
dc.contributor.author | WANG, Yuxuan | - |
dc.contributor.author | AGRAWAL, Nishant | - |
dc.contributor.author | BARTLETT, Bjarne R. | - |
dc.contributor.author | WANG, Hao | - |
dc.contributor.author | LUBER, Brandon | - |
dc.contributor.author | ALANI, Rhoda M. | - |
dc.contributor.author | ANTONARAKIS, Emmanuel S. | - |
dc.contributor.author | AZAD, Nilofer S. | - |
dc.contributor.author | BARDELLI, Alberto | - |
dc.contributor.author | BREM, Henry | - |
dc.contributor.author | CAMERON, John L. | - |
dc.contributor.author | LEE, Clarence C. | - |
dc.contributor.author | FECHER, Leslie A. | - |
dc.contributor.author | GALLIA, Gary L. | - |
dc.contributor.author | GIBBS, Peter | - |
dc.contributor.author | LE, Dung | - |
dc.contributor.author | GIUNTOLI, Robert L. | - |
dc.contributor.author | GOGGINS, Michael | - |
dc.contributor.author | HOGARTY, Michael D. | - |
dc.contributor.author | HOLDHOFF, Matthias | - |
dc.contributor.author | HONG, Seung-Mo | - |
dc.contributor.author | JIAO, Yuchen | - |
dc.contributor.author | JUHL, Hartmut H. | - |
dc.contributor.author | KIM, Jenny J. | - |
dc.contributor.author | SIRAVEGNA, Giulia | - |
dc.contributor.author | LAHERU, Daniel A. | - |
dc.contributor.author | LAURICELLA, Calogero | - |
dc.contributor.author | LIM, Michael | - |
dc.contributor.author | LIPSON, Evan J. | - |
dc.contributor.author | MARIE, Suely Kazue Nagahashi | - |
dc.contributor.author | NETTO, George J. | - |
dc.contributor.author | OLINER, Kelly S. | - |
dc.contributor.author | OLIVI, Alessandro | - |
dc.contributor.author | OLSSON, Louise | - |
dc.contributor.author | RIGGINS, Gregory J. | - |
dc.contributor.author | SARTORE-BIANCHI, Andrea | - |
dc.contributor.author | SCHMIDT, Kerstin | - |
dc.contributor.author | SHIH, Ie-Ming | - |
dc.contributor.author | OBA-SHINJO, Sueli Mieko | - |
dc.contributor.author | SIENA, Salvatore | - |
dc.contributor.author | THEODORESCU, Dan | - |
dc.contributor.author | TIE, Jeanne | - |
dc.contributor.author | HARKINS, Timothy T. | - |
dc.contributor.author | VERONESE, Silvio | - |
dc.contributor.author | WANG, Tian-Li | - |
dc.contributor.author | WEINGART, Jon D. | - |
dc.contributor.author | WOLFGANG, Christopher L. | - |
dc.contributor.author | WOOD, Laura D. | - |
dc.contributor.author | XING, Dongmei | - |
dc.contributor.author | HRUBAN, Ralph H. | - |
dc.contributor.author | WU, Jian | - |
dc.contributor.author | ALLEN, Peter J. | - |
dc.contributor.author | SCHMIDT, C. Max | - |
dc.contributor.author | CHOTI, Michael A. | - |
dc.contributor.author | VELCULESCU, Victor E. | - |
dc.contributor.author | KINZLER, Kenneth W. | - |
dc.contributor.author | VOGELSTEIN, Bert | - |
dc.contributor.author | PAPADOPOULOS, Nickolas | - |
dc.contributor.author | DIAZ JR., Luis A. | - |
dc.date.accessioned | 2014-04-28T22:02:23Z | - |
dc.date.available | 2014-04-28T22:02:23Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | SCIENCE TRANSLATIONAL MEDICINE, v.6, n.224, 2014 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5398 | - |
dc.description.abstract | The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction-based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types. We found that ctDNA was detectable in > 75% of patients with advanced pancreatic, ovarian, colorectal, bladder, gastroesophageal, breast, melanoma, hepatocellular, and head and neck cancers, but in less than 50% of primary brain, renal, prostate, or thyroid cancers. In patients with localized tumors, ctDNA was detected in 73, 57, 48, and 50% of patients with colorectal cancer, gastroesophageal cancer, pancreatic cancer, and breast adenocarcinoma, respectively. ctDNA was often present in patients without detectable circulating tumor cells, suggesting that these two biomarkers are distinct entities. In a separate panel of 206 patients with metastatic colorectal cancers, we showed that the sensitivity of ctDNA for detection of clinically relevant KRAS gene mutations was 87.2% and its specificity was 99.2%. Finally, we assessed whether ctDNA could provide clues into the mechanisms underlying resistance to epidermal growth factor receptor blockade in 24 patients who objectively responded to therapy but subsequently relapsed. Twenty-three (96%) of these patients developed one or more mutations in genes involved in the mitogen-activated protein kinase pathway. Together, these data suggest that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes in patients with multiple different types of cancer. | - |
dc.description.sponsorship | NIGMS NIH HHS | - |
dc.description.sponsorship | NIDCR NIH HHS | - |
dc.description.sponsorship | NCI NIH HHS | - |
dc.language.iso | eng | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.relation.ispartof | Science Translational Medicine | - |
dc.rights | restrictedAccess | - |
dc.subject.other | metastatic colorectal-cancer | - |
dc.subject.other | cell lung-cancer | - |
dc.subject.other | acquired-resistance | - |
dc.subject.other | kras mutations | - |
dc.subject.other | ras mutations | - |
dc.subject.other | breast-cancer | - |
dc.subject.other | plasma dna | - |
dc.subject.other | egfr | - |
dc.subject.other | cetuximab | - |
dc.subject.other | genome | - |
dc.title | Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies | - |
dc.type | article | - |
dc.rights.holder | Copyright AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.identifier.doi | 10.1126/scitranslmed.3007094 | - |
dc.subject.wos | Cell Biology | - |
dc.subject.wos | Medicine, Research & Experimental | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BETTEGOWDA, Chetan:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | SAUSEN, Mark:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | LEARY, Rebecca J.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | KINDE, Isaac:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WANG, Yuxuan:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | AGRAWAL, Nishant:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | BARTLETT, Bjarne R.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; Johns Hopkins, Swim Amer Lab, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WANG, Hao:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | LUBER, Brandon:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | ALANI, Rhoda M.:Boston Univ, Dept Dermatol, Boston, MA 02215 USA | - |
hcfmusp.author.external | ANTONARAKIS, Emmanuel S.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | AZAD, Nilofer S.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | BARDELLI, Alberto:Univ Turin, Inst Canc Res & Treatment Candiolo, I-10060 Turin, Italy; Univ Turin, Dept Oncol, I-10060 Turin, Italy; IFOM, I-20139 Milan, Italy | - |
hcfmusp.author.external | BREM, Henry:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | CAMERON, John L.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | LEE, Clarence C.:Life Technol, Adv Applicat & Collaborat, Foster City, CA 94404 USA | - |
hcfmusp.author.external | FECHER, Leslie A.:Indiana Univ, Div Oncol, Indianapolis, IN 46202 USA; Indiana Univ Hlth, Indianapolis, IN 46202 USA | - |
hcfmusp.author.external | GALLIA, Gary L.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | GIBBS, Peter:Royal Melbourne Hosp, Melbourne Branch, Ludwig Inst Canc Res, Melbourne, Vic 3084, Australia; Western Hosp, Melbourne, Vic 3011, Australia | - |
hcfmusp.author.external | LE, Dung:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; Johns Hopkins, Swim Amer Lab, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | GIUNTOLI, Robert L.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | GOGGINS, Michael:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | HOGARTY, Michael D.:Childrens Hosp Philadelphia, Sch Med, Div Oncol, Philadelphia, PA 19104 USA; Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA | - |
hcfmusp.author.external | HOLDHOFF, Matthias:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | HONG, Seung-Mo:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea | - |
hcfmusp.author.external | JIAO, Yuchen:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | JUHL, Hartmut H.:Indivumed GmbH, D-20251 Hamburg, Germany | - |
hcfmusp.author.external | KIM, Jenny J.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | SIRAVEGNA, Giulia:Osped Niguarda Ca Granda, Niguarda Canc Ctr, I-20162 Milan, Italy | - |
hcfmusp.author.external | LAHERU, Daniel A.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | LAURICELLA, Calogero:Osped Niguarda Ca Granda, Niguarda Canc Ctr, I-20162 Milan, Italy | - |
hcfmusp.author.external | LIM, Michael:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | LIPSON, Evan J.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | NETTO, George J.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | OLINER, Kelly S.:Amgen Inc, Thousand Oaks, CA 91320 USA | - |
hcfmusp.author.external | OLIVI, Alessandro:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | OLSSON, Louise:Karolinska Inst, Dept Mol Med & Surg, SE-17176 Stockholm, Sweden | - |
hcfmusp.author.external | RIGGINS, Gregory J.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | SARTORE-BIANCHI, Andrea:Osped Niguarda Ca Granda, Niguarda Canc Ctr, I-20162 Milan, Italy | - |
hcfmusp.author.external | SCHMIDT, Kerstin:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | SHIH, Ie-Ming:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | SIENA, Salvatore:Osped Niguarda Ca Granda, Niguarda Canc Ctr, I-20162 Milan, Italy | - |
hcfmusp.author.external | THEODORESCU, Dan:Univ Colorado, Ctr Comprehens Canc, Aurora, CO 80045 USA | - |
hcfmusp.author.external | TIE, Jeanne:Royal Melbourne Hosp, Melbourne Branch, Ludwig Inst Canc Res, Melbourne, Vic 3084, Australia | - |
hcfmusp.author.external | HARKINS, Timothy T.:Life Technol, Adv Applicat & Collaborat, Foster City, CA 94404 USA | - |
hcfmusp.author.external | VERONESE, Silvio:Osped Niguarda Ca Granda, Niguarda Canc Ctr, I-20162 Milan, Italy | - |
hcfmusp.author.external | WANG, Tian-Li:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WEINGART, Jon D.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WOLFGANG, Christopher L.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WOOD, Laura D.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | XING, Dongmei:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | HRUBAN, Ralph H.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | WU, Jian:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; MyGenostics Inc, Baltimore, MD 21205 USA | - |
hcfmusp.author.external | ALLEN, Peter J.:Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA | - |
hcfmusp.author.external | SCHMIDT, C. Max:Indiana Univ, Dept Surg, Indianapolis, IN 46202 USA; Indiana Univ, Dept Biochem, Indianapolis, IN 46202 USA; Indiana Univ, Dept Mol Biol, Indianapolis, IN 46202 USA | - |
hcfmusp.author.external | CHOTI, Michael A.:Johns Hopkins, Dept Surg, Baltimore, MD 21231 USA; Johns Hopkins, Dept Med, Baltimore, MD 21231 USA; Johns Hopkins, Dept Pathol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Obstet & Gynecol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Otolaryngol, Baltimore, MD 21231 USA; Johns Hopkins, Dept Neurosurg, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | VELCULESCU, Victor E.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | KINZLER, Kenneth W.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | VOGELSTEIN, Bert:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | PAPADOPOULOS, Nickolas:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA | - |
hcfmusp.author.external | DIAZ JR., Luis A.:Howard Hughes Med Inst, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA; Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA; Johns Hopkins, Swim Amer Lab, Baltimore, MD 21231 USA | - |
hcfmusp.description.issue | 224 | - |
hcfmusp.description.volume | 6 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000331476700004 | - |
hcfmusp.origem.id | 2-s2.0-84896371874 | - |
hcfmusp.publisher.city | WASHINGTON | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1946-6242 | - |
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hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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