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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorARAUJO, D. B.-
dc.contributor.authorBORBA, E. F.-
dc.contributor.authorSILVA, C. A.-
dc.contributor.authorCAMPOS, L. M. A.-
dc.contributor.authorPEREIRA, R. M. R.-
dc.contributor.authorBONFA, E.-
dc.contributor.authorSHINJO, S. K.-
dc.date.accessioned2013-07-30T14:42:03Z-
dc.date.available2013-07-30T14:42:03Z-
dc.date.issued2012-
dc.identifier.citationLUPUS, v.21, n.8, p.872-877, 2012-
dc.identifier.issn0961-2033-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/539-
dc.description.abstractWe compared outcomes of alveolar hemorrhage (AH) in juvenile (JSLE) and adult onset SLE (ASLE). From 263 JSLE and 1522 ASLE, the AH occurred in 13 (4.9%) and 15 (1.0%) patients, respectively (p < .001). Both groups had comparable disease duration (2.6 +/- 3.0 vs. 5.6 +/- 7.0 years, p = .151) and median SLEDAI scores [17.5 (2 to 32) vs. 17.5 (3 to 28), p = 1.000]. At AH onset, a higher frequency of JSLE were already on a high prednisone dose ( > 0.5 mg/kg/day) compared to ASLE (54% vs. 15%, p = .042). The mean drop of hemoglobin was significantly lower in JSLE (2.9 +/- 0.9 vs. 5.5 +/- 2.9 g/dL, p = .006). Although treatments with methylprednisolone, plasmapheresis, intravenous immunoglobulin and cyclophosphamide were similar in both groups (p > .050), regarding outcomes, there was a trend in high frequency of mechanical ventilation use (85% vs. 47%, p = .055) and also significant mortality (69% vs. 13%, p = .006) in JSLE compared to ASLE. The sepsis frequency was comparable in both groups (50% vs. 27%, p = .433). We have identified that AH in JSLE has a worse outcome most likely related to respiratory failure. The AH onset in JSLE already treated with high-dose steroids raises the concern of inadequate response to this treatment and reinforces the recommendation of early aggressive alternative therapies in this group of patients. Lupus (2012) 21, 872-877.-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [303165/2008-1, 300248/2008-3, 300559/2009-7, 301411/2009-3]-
dc.description.sponsorshipFederico Foundation-
dc.language.isoeng-
dc.publisherSAGE PUBLICATIONS LTD-
dc.relation.ispartofLupus-
dc.rightsrestrictedAccess-
dc.subjectAlveolar hemorrhage-
dc.subjectjuvenile systemic lupus erythematosus-
dc.subjectmortality-
dc.subjectsystemic lupus erythematosus-
dc.subjectpulmonary-
dc.subject.othermacrophage activation syndrome-
dc.subject.otherpulmonary hemorrhage-
dc.subject.otherclinical-features-
dc.subject.otherchildhood-onset-
dc.subject.otherantibodies-
dc.subject.othercriteria-
dc.subject.otherdiseases-
dc.subject.otherprotein-
dc.subject.otherindex-
dc.titleAlveolar hemorrhage: distinct features of juvenile and adult onset systemic lupus erythematosus-
dc.typearticle-
dc.rights.holderCopyright SAGE PUBLICATIONS LTD-
dc.identifier.doi10.1177/0961203312441047-
dc.identifier.pmid22427319-
dc.subject.wosRheumatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.description.beginpage872-
hcfmusp.description.endpage877-
hcfmusp.description.issue8-
hcfmusp.description.volume21-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84861806789-
hcfmusp.origem.idWOS:000304703500009-
hcfmusp.publisher.cityLONDON-
hcfmusp.publisher.countryENGLAND-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFederico Foundation-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFederico Foundation-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus36-
hcfmusp.scopus.lastupdate2022-06-24-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica


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