Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/539
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | ARAUJO, D. B. | - |
dc.contributor.author | BORBA, E. F. | - |
dc.contributor.author | SILVA, C. A. | - |
dc.contributor.author | CAMPOS, L. M. A. | - |
dc.contributor.author | PEREIRA, R. M. R. | - |
dc.contributor.author | BONFA, E. | - |
dc.contributor.author | SHINJO, S. K. | - |
dc.date.accessioned | 2013-07-30T14:42:03Z | - |
dc.date.available | 2013-07-30T14:42:03Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | LUPUS, v.21, n.8, p.872-877, 2012 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/539 | - |
dc.description.abstract | We compared outcomes of alveolar hemorrhage (AH) in juvenile (JSLE) and adult onset SLE (ASLE). From 263 JSLE and 1522 ASLE, the AH occurred in 13 (4.9%) and 15 (1.0%) patients, respectively (p < .001). Both groups had comparable disease duration (2.6 +/- 3.0 vs. 5.6 +/- 7.0 years, p = .151) and median SLEDAI scores [17.5 (2 to 32) vs. 17.5 (3 to 28), p = 1.000]. At AH onset, a higher frequency of JSLE were already on a high prednisone dose ( > 0.5 mg/kg/day) compared to ASLE (54% vs. 15%, p = .042). The mean drop of hemoglobin was significantly lower in JSLE (2.9 +/- 0.9 vs. 5.5 +/- 2.9 g/dL, p = .006). Although treatments with methylprednisolone, plasmapheresis, intravenous immunoglobulin and cyclophosphamide were similar in both groups (p > .050), regarding outcomes, there was a trend in high frequency of mechanical ventilation use (85% vs. 47%, p = .055) and also significant mortality (69% vs. 13%, p = .006) in JSLE compared to ASLE. The sepsis frequency was comparable in both groups (50% vs. 27%, p = .433). We have identified that AH in JSLE has a worse outcome most likely related to respiratory failure. The AH onset in JSLE already treated with high-dose steroids raises the concern of inadequate response to this treatment and reinforces the recommendation of early aggressive alternative therapies in this group of patients. Lupus (2012) 21, 872-877. | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [303165/2008-1, 300248/2008-3, 300559/2009-7, 301411/2009-3] | - |
dc.description.sponsorship | Federico Foundation | - |
dc.language.iso | eng | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.relation.ispartof | Lupus | - |
dc.rights | restrictedAccess | - |
dc.subject | Alveolar hemorrhage | - |
dc.subject | juvenile systemic lupus erythematosus | - |
dc.subject | mortality | - |
dc.subject | systemic lupus erythematosus | - |
dc.subject | pulmonary | - |
dc.subject.other | macrophage activation syndrome | - |
dc.subject.other | pulmonary hemorrhage | - |
dc.subject.other | clinical-features | - |
dc.subject.other | childhood-onset | - |
dc.subject.other | antibodies | - |
dc.subject.other | criteria | - |
dc.subject.other | diseases | - |
dc.subject.other | protein | - |
dc.subject.other | index | - |
dc.title | Alveolar hemorrhage: distinct features of juvenile and adult onset systemic lupus erythematosus | - |
dc.type | article | - |
dc.rights.holder | Copyright SAGE PUBLICATIONS LTD | - |
dc.identifier.doi | 10.1177/0961203312441047 | - |
dc.identifier.pmid | 22427319 | - |
dc.subject.wos | Rheumatology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 872 | - |
hcfmusp.description.endpage | 877 | - |
hcfmusp.description.issue | 8 | - |
hcfmusp.description.volume | 21 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84861806789 | - |
hcfmusp.origem.id | WOS:000304703500009 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
hcfmusp.relation.reference | ABUDMENDOZA C, 1985, J RHEUMATOL, V12, P558 | - |
hcfmusp.relation.reference | Aikawa NE, 2009, ISR MED ASSOC J, V11, P635 | - |
hcfmusp.relation.reference | Barile LA, 1997, LUPUS, V6, P445, DOI 10.1177/096120339700600506 | - |
hcfmusp.relation.reference | BOMBARDIER C, 1992, ARTHRITIS RHEUM, V35, P630, DOI 10.1002/art.1780350606 | - |
hcfmusp.relation.reference | BONFA E, 1987, NEW ENGL J MED, V317, P265, DOI 10.1056/NEJM198707303170503 | - |
hcfmusp.relation.reference | BRANDT JT, 1995, THROMB HAEMOSTASIS, V74, P1185 | - |
hcfmusp.relation.reference | Brunner HI, 2008, ARTHRITIS RHEUM, V58, P556, DOI 10.1002/art.23204 | - |
hcfmusp.relation.reference | Campos LMA, 2010, LUPUS, V19, P1654, DOI 10.1177/0961203310378863 | - |
hcfmusp.relation.reference | COSTALLAT LTL, 1994, CLIN EXP RHEUMATOL, V12, P603 | - |
hcfmusp.relation.reference | EAGEN JW, 1978, MEDICINE, V57, P545, DOI 10.1097/00005792-197811000-00005 | - |
hcfmusp.relation.reference | ELKON KB, 1984, J IMMUNOL, V132, P2350 | - |
hcfmusp.relation.reference | Fukaya S, 2008, RHEUMATOLOGY, V47, P1686, DOI 10.1093/rheumatology/ken342 | - |
hcfmusp.relation.reference | GHARAVI AE, 1987, ANN RHEUM DIS, V46, P1, DOI 10.1136/ard.46.1.1 | - |
hcfmusp.relation.reference | Gladman D, 1996, ARTHRITIS RHEUM, V39, P363, DOI 10.1002/art.1780390303 | - |
hcfmusp.relation.reference | Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928 | - |
hcfmusp.relation.reference | Hoffman IEA, 2009, ANN RHEUM DIS, V68, P412, DOI 10.1136/ard.2008.094813 | - |
hcfmusp.relation.reference | Koh WH, 1997, LUPUS, V6, P713, DOI 10.1177/096120339700600906 | - |
hcfmusp.relation.reference | KURATA N, 1976, ARTHRITIS RHEUM, V19, P574, DOI 10.1002/art.1780190309 | - |
hcfmusp.relation.reference | Kwok SK, 2011, LUPUS, V20, P102, DOI 10.1177/0961203310381511 | - |
hcfmusp.relation.reference | Lee JG, 2000, CLIN NEPHROL, V54, P282 | - |
hcfmusp.relation.reference | Liu MF, 1998, SCAND J RHEUMATOL, V27, P291 | - |
hcfmusp.relation.reference | Marino CT, 1991, ARCH INTERN MED, V141, P201 | - |
hcfmusp.relation.reference | Martinez-Martinez MU, 2011, LUPUS, V20, P568, DOI 10.1177/0961203310392430 | - |
hcfmusp.relation.reference | Osler W, 1904, AM J MED SCI, V127, P1, DOI 10.1097/00000441-190401000-00001 | - |
hcfmusp.relation.reference | Parodi A, 2009, ARTHRITIS RHEUM, V60, P3388, DOI 10.1002/art.24883 | - |
hcfmusp.relation.reference | Santos-Ocampo AS, 2000, CHEST, V118, P1083, DOI 10.1378/chest.118.4.1083 | - |
hcfmusp.relation.reference | SCHWAB EP, 1993, SEMIN ARTHRITIS RHEU, V23, P8, DOI 10.1016/S0049-0172(05)80022-8 | - |
hcfmusp.relation.reference | Silva Clovis Artur A, 2004, J Pediatr (Rio J), V80, P517, DOI 10.2223/JPED.1267 | - |
hcfmusp.relation.reference | Tan EM, 1980, MANUAL CLIN IMMUNOLO, P866 | - |
hcfmusp.relation.reference | Badsha H, 2004, SEMIN ARTHRITIS RHEU, V33, P414, DOI 10.1053/S0049-0172(03)00163-X | - |
hcfmusp.relation.reference | TUCKER LB, 1995, BRIT J RHEUMATOL, V34, P866 | - |
hcfmusp.relation.reference | Zamora MR, 1997, MEDICINE, V76, P192, DOI 10.1097/00005792-199705000-00005 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | Federico Foundation | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | Federico Foundation | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 39 | - |
hcfmusp.scopus.lastupdate | 2024-02-23 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/36 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_ARAUJO_Alveolar_hemorrhage_distinct_features_of_juvenile_and_adult_2012.PDF Restricted Access | publishedVersion (English) | 117.66 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.