https://observatorio.fm.usp.br/handle/OPI/5416
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SOUZA, Marilene Alicia | - |
dc.contributor.author | FONSECA, Angela de Maggio da | - |
dc.contributor.author | BAGNOLI, Vicente Renato | - |
dc.contributor.author | BARROS, Nestor de | - |
dc.contributor.author | NEVES, Erica Mendonca das | - |
dc.contributor.author | MORAES, Sandra Dircinha Teixeira de Araujo | - |
dc.contributor.author | HORTENSE, Victor Hugo Souza | - |
dc.contributor.author | SOARES, Jose Maria | - |
dc.contributor.author | BARACAT, Edmund Chada | - |
dc.date.accessioned | 2014-04-28T22:03:13Z | - |
dc.date.available | 2014-04-28T22:03:13Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | GYNECOLOGICAL ENDOCRINOLOGY, v.30, n.1, p.78-80, 2014 | - |
dc.identifier.issn | 0951-3590 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5416 | - |
dc.description.abstract | Objective: Obesity has been associated with increased risk for breast cancer (BC) mortality. Verifying in women with high breast density (HBD) post-menopausal, the frequency of polymorphisnns of estrogen receptor (ER)alpha-Pvull, ER alpha-Xbal and if they influence the body mass index (BMI). Methods: Study with 308 women with HBD post-menopause divided into two groups according to BMI: 1st group = BMI <25 kg/m(2), 2nd group = BMI >= 25 kg/m(2). It was characterized in the clinical history: menarche, menopause, parity, family history of BC, smoking and alcohol intake. Results: Allele and genotype frequencies for the ER alpha-397-Pvull and ER alpha-351-Xbal: P =43.99%, p =56.01%, pp =32.14%, Pp =47.73%, PP =X =20.13% and X=41.56%, x=58.44%; xx = 33.44%; Xx =50.00%; XX =16.56%, respectively. Both Pvull and Xbal influenced BMI. When Xbal is mutated the tendency is toward higher BMI (0.039), and women with lower BMI were more frequent in Pvull genotype (p = 0.002). More frequent risk factors for BC: menarche before the age of 12 years (35.38%), nulliparity or 1st child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%). Conclusion: Variations in the ER alpha gene affected the BMI in women with HBD, who already are at increased risk for BC. | - |
dc.language.iso | eng | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.relation.ispartof | Gynecological Endocrinology | - |
dc.rights | restrictedAccess | - |
dc.subject | Breast cancer | - |
dc.subject | estrogen receptors | - |
dc.subject | genetic polymorphism | - |
dc.subject | mammography | - |
dc.subject | obesity | - |
dc.subject | risk factors | - |
dc.subject.other | body-mass index | - |
dc.subject.other | genetic polymorphisms | - |
dc.subject.other | united-states | - |
dc.subject.other | cancer | - |
dc.subject.other | alpha | - |
dc.subject.other | women | - |
dc.subject.other | risk | - |
dc.subject.other | association | - |
dc.title | The expression of the estrogen receptor in obese patients with high breast density (HBD) | - |
dc.type | article | - |
dc.rights.holder | Copyright INFORMA HEALTHCARE | - |
dc.identifier.doi | 10.3109/09513590.2013.859669 | - |
dc.identifier.pmid | 24266697 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.subject.wos | Obstetrics & Gynecology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | NEVES, Erica Mendonca das:Univ Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil | - |
hcfmusp.author.external | MORAES, Sandra Dircinha Teixeira de Araujo:Univ Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil | - |
hcfmusp.author.external | HORTENSE, Victor Hugo Souza:Univ Catholic Curitiba, Curitiba, Parana, Brazil | - |
hcfmusp.description.beginpage | 78 | - |
hcfmusp.description.endpage | 80 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 30 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000329952900017 | - |
hcfmusp.origem.id | 2-s2.0-84890482032 | - |
hcfmusp.publisher.city | NEW YORK | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1473-0766 | - |
hcfmusp.citation.scopus | 6 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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