Please use this identifier to cite or link to this item:
Title: Respiratory toxicity of repeated exposure to particles produced by traffic and sugar cane burning
Authors: MAZZOLI-ROCHA, FlaviaCARVALHO, Giovanna M. C.LANZETTI, ManuellaVALENCA, Samuel S.SILVA, Luiz F. F.SALDIVA, Paulo H. N.ZIN, Walter A.FAFFE, Debora S.
Citation: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.191, p.106-113, 2014
Abstract: We compared the toxicity of subchronic exposure to equivalent masses of particles from sugar cane burning and traffic. BALB/c mice received 3 intranasal instillations/week during 1, 2 or 4 weeks of either distilled water (C1, C2, C4) or particles (15 mu g) from traffic (UP1, UP2, UP4) or biomass burning (BP1, BP2, BP4). Lung mechanics, histology and oxidative stress were analyzed 24 h after the last instillation. In all instances UP and BP groups presented worse pulmonary elastance, airway and tissue resistance, alveolar collapse, bronchoconstriction and macrophage influx into the lungs than controls. UP4, BP2 and BP4 presented more alveolar collapse than UP1 and BP1, respectively. UP and BP had worse bronchial and alveolar lesion scores than their controls; BP4 had greater bronchial lesion scores than UP4. Catalase was higher in UP4 and BP4 than in C4. In conclusion, biomass particles were more toxic than those from traffic after repeated exposures.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)1.55 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.