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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorKILLIAN, Megan L.-
dc.contributor.authorCAVINATTO, Leonardo-
dc.contributor.authorSHAH, Shivam A.-
dc.contributor.authorSATO, Eugene J.-
dc.contributor.authorWARD, Samuel R.-
dc.contributor.authorHAVLIOGLU, Necat-
dc.contributor.authorGALATZ, Leesa M.-
dc.contributor.authorTHOMOPOULOS, Stavros-
dc.identifier.citationJOURNAL OF ORTHOPAEDIC RESEARCH, v.32, n.3, p.439-447, 2014-
dc.description.abstractThe objective of this study was to understand the effect of pre-repair rotator cuff chronicity on post-repair healing outcomes using a chronic and acute multi-tendon rat rotator cuff injury model. Full-thickness dual tendon injuries (supra- and infraspinatus) were created unilaterally in adult male Sprague Dawley rats, and left chronically detached for 8 or 16 weeks. After chronic detachment, tears were repaired and acute dual tendon injuries were created and immediately repaired on contralateral shoulders. Tissue level outcomes for bone, tendon, and muscle were assessed 4 or 8 weeks after repair using histology, microcomputed tomography, biomechanical testing, and biochemical assays. Substantial gap formation was seen in 35% of acute repairs and 44% of chronic repairs. Gap formation negatively correlated with mechanical and structural outcomes for both healing time points regardless of injury duration. Bone and histomorphometry, as well as biomechanics, were similar between acute and chronic injury and repair regardless of chronicity and duration of healing. This study was the first to implement a multi-tendon rotator cuff injury with surgical repair following both chronic and acute injuries. Massive tear in a rodent model resulted in gap formation regardless of injury duration which had detrimental effects on repair outcomes. (c) 2013 Orthopaedic Research Society.-
dc.description.sponsorshipNational Institutes of Health/National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIH-NIAMS) [R01 AR057836]-
dc.description.sponsorshipWashington University Musculoskeletal Research Center [NIH P30 AR057235]-
dc.description.sponsorshipNational Skeletal Muscle Research Center [NIH R24 HD050837]-
dc.relation.ispartofJournal of Orthopaedic Research-
dc.subjectrotator cuff-
dc.subject.otherfull-thickness tears-
dc.subject.otherarthroscopic repair-
dc.subject.otherflexor tendons-
dc.subject.othercanine model-
dc.titleThe Effects of Chronic Unloading and Gap Formation on Tendon-to-bone Healing in a Rat Model of Massive Rotator Cuff Tears-
dc.rights.holderCopyright WILEY-BLACKWELL-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Megan L.:Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA-, Shivam A.:Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA-, Eugene J.:Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA; Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA; Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA-, Samuel R.:Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA; Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA; Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA-, Necat:John Cochran Vet Affairs Med Ctr, St Louis, MO 63106 USA-, Leesa M.:Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA-, Stavros:Washington Univ, Dept Orthopaed Surg, St Louis, MO 63110 USA-
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