Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/5487
Title: Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis
Authors: BASSI, E.LIBERMAN, M.MARTINATTI, M. K.BORTOLOTTO, L. A.LAURINDO, F. R. M.
Citation: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.47, n.2, p.119-127, 2014
Abstract: Vascular calcification decreases compliance and increases morbidity. Mechanisms of this process are unclear. The role of oxidative stress and effects of antioxidants have been poorly explored. We investigated effects of the antioxidants lipoic acid (LA) and tempol in a model of atherosclerosis associated with elastocalcinosis. Male New Zealand white rabbits (2.5-3.0 kg) were fed regular chow (controls) or a 0.5% cholesterol (chol) diet + 10(4) IU/day vitamin D-2 (vitD) for 12 weeks, and assigned to treatment with water (vehicle, n= 20), 0.12 mmol.kg(-1).day(-1) LA (n= 11) or 0.1 mmol.kg(-1).day(-1) tempol (n= 15). Chol + vitD-fed rabbits developed atherosclerotic plaques associated with expansive remodeling, elastic fiber disruption, medial calcification, and increased aortic stiffness. Histologically, LA prevented medial calcification by similar to 60% and aortic stiffening by similar to 60%. LA also preserved responsiveness to constrictor agents, while intima-media thickening was increased. In contrast to LA, tempol was associated with increased plaque collagen content, medial calcification and aortic stiffness, and produced differential changes in vasoactive responses in the chol + vitD group. Both LA and tempol prevented superoxide signals with chol + vitD. However, only LA prevented hydrogen peroxide-related signals with chol + vitD, while tempol enhanced them. These data suggest that LA, opposite to tempol, can minimize calcification and compliance loss in elastocalcionosis by inhibition of hydrogen peroxide generation.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

Artigos e Materiais de Revistas Científicas - ODS/07
ODS/07 - Energia limpa e acessível


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