Departamento de Patologia - FM/MPT
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Acupuntura para o tratamento da dor
Tsai, André Wan Wen; Lin, Chin An; D´Alessandro, Eduardo Guilherme; Hsing, Wu Tu. Acupuntura para o tratamento da dor. In: Liggieri, André Cicone; Tsai, André Wan Wen; Machado, Edison Silva; Moraes, Frederico Barra de; Liu, Ibrahim Afrânio Willi; Forni, José Eduardo Nogueira; Fim, Márcio (eds); Kobayashi, Ricardo; Luzo, Marcus Vinicius Malheiros; Cohen, Moisés (coords). Tratado de dor musculoesquelética. SÃO PAULO: Alef, 2019. p.505-514.
Strong response after fourth dose of mRNA COVID-19 vaccine in autoimmune rheumatic diseases patients with poor response to inactivated vaccine
RHEUMATOLOGY, v.62, n.1, p.480-485, 2022
Objectives. To assess immunogenicity of a heterologous fourth dose of an mRNA (BNT162b2) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in autoimmune rheumatic diseases (ARD) patients with poor/non-response to inactivated vaccine (Sinovac-CoronaVac). Methods. A total of 164 ...
Early variation of inflammatory indexes refines prognostic prediction in patients with hepatocellular carcinoma under systemic treatment
MOLECULAR AND CLINICAL ONCOLOGY, v.18, n.4, article ID 29, 8p, 2023
Prognostic markers in advanced hepatocellular carcinoma (HCC) are relevant for clinical decisions. Variations in inflammatory indexes, such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR), may correlate with outcomes. In the present study, it was aimed to assess the ...
Experimental Yellow Fever in Squirrel Monkey: Characterization of Liver In Situ Immune Response
VIRUSES-BASEL, v.15, n.2, article ID 551, 16p, 2023
Non-human primates contribute to the spread of yellow fever virus (YFV) and the establishment of transmission cycles in endemic areas, such as Brazil. This study aims to investigate virological, histopathological and immunohistochemical findings in livers of squirrel monkeys (Saimiri spp.) infect...
Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling
FRONTIERS IN MOLECULAR BIOSCIENCES, v.10, article ID 1051494, 15p, 2023
Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across MAPT mutations remain poorly understood. The go...
Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, n.5, article ID 4719, 16p, 2023
Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects in ast...
The need for integrated research autopsies in the era of precision oral medicine
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, v.154, n.3, p.194-205, 2023
Background. Autopsy has benefited the practice of medicine for centuries; however, its use to advance the practice of oral health care is relatively limited. In the era of precision oral medicine, the research autopsy is poised to play an important role in understanding oral-systemic health, incl...
Imbalanced IL-1B and IL-18 Expression in Sezary Syndrome
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, n.5, article ID 4674, 13p, 2023
Sezary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to the active form by inflammasomes...
Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus
VIRUSES-BASEL, v.15, n.2, article ID 320, 15p, 2023
Obesity is increasing in incidence worldwide, especially in women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) outbreak in Brazil has been the cause of congenital Zika synd...
Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study
MOLECULAR NEUROBIOLOGY, v.60, n.4, p.2174-2185, 2023
Temporal lobe epilepsy (TLE) often courses with cognitive deficits, but its underlying neuronal basis remains unclear. Confluent data suggest that epilepsy share pathophysiological mechanisms with neurodegenerative diseases. However, as most studies analyze subjects 60 years old and older, it is ...