Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/5533
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBARBOSA, Izabela Guimaraes-
dc.contributor.authorMACHADO-VIEIRA, Rodrigo-
dc.contributor.authorSOARES, Jair C.-
dc.contributor.authorTEIXEIRA, Antonio L.-
dc.date.accessioned2014-04-28T22:25:17Z-
dc.date.available2014-04-28T22:25:17Z-
dc.date.issued2014-
dc.identifier.citationNEUROIMMUNOMODULATION, v.21, n.2-3, p.117-122, 2014-
dc.identifier.issn1021-7401-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5533-
dc.description.abstractBipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD. (C) 2014 S. Karger AG, Basel-
dc.description.sponsorshipCNPq-
dc.description.sponsorshipFAPEMIG, Brazil-
dc.description.sponsorshipStanley Medical Research Institute-
dc.description.sponsorshipCAPES scholarship-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP), Brazil-
dc.description.sponsorshipNational Institute of Mental Health (NIH), USA-
dc.language.isoeng-
dc.publisherKARGER-
dc.relation.ispartofNeuroimmunomodulation-
dc.rightsopenAccess-
dc.subjectMania-
dc.subjectDepression-
dc.subjectAspirin-
dc.subjectInterleukin-
dc.subjectLymphocytes-
dc.subjectMood disorder-
dc.subject.otherautoimmune-thyroiditis-
dc.subject.otherlithium treatment-
dc.subject.otheroxidative stress-
dc.subject.othermood disorders-
dc.subject.otherimmune-system-
dc.subject.otheracute mania-
dc.subject.othert-cells-
dc.subject.othercytokines-
dc.subject.otherschizophrenia-
dc.subject.otherinflammation-
dc.titleThe Immunology of Bipolar Disorder-
dc.typearticle-
dc.rights.holderCopyright KARGER-
dc.identifier.doi10.1159/000356539-
dc.identifier.pmid24557044-
dc.subject.wosEndocrinology & Metabolism-
dc.subject.wosImmunology-
dc.subject.wosNeurosciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalBARBOSA, Izabela Guimaraes:Univ Fed Minas Gerais, Lab Interdisciplinar Invest Med, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil-
hcfmusp.author.externalSOARES, Jair C.:UTHlth Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA-
hcfmusp.author.externalTEIXEIRA, Antonio L.:Univ Fed Minas Gerais, Lab Interdisciplinar Invest Med, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, IEAT, BR-30130100 Belo Horizonte, MG, Brazil-
hcfmusp.description.beginpage117-
hcfmusp.description.endpage122-
hcfmusp.description.issue2-3-
hcfmusp.description.volume21-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84907881516-
hcfmusp.origem.idWOS:000331488100008-
hcfmusp.publisher.cityBASEL-
hcfmusp.publisher.countrySWITZERLAND-
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dc.description.indexMEDLINE-
dc.identifier.eissn1423-0216-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPEMIG-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipNIH-
hcfmusp.remissive.sponsorshipStanley-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPEMIG-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipNIH-
hcfmusp.remissive.sponsorshipStanley-
hcfmusp.citation.scopus96-
hcfmusp.scopus.lastupdate2022-04-15-
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