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https://observatorio.fm.usp.br/handle/OPI/5541
Title: | Inability to Detect Human T Cell Lymphotropic Virus Type 2-Specific Antibodies in a Patient Coinfected with HIV-1, Human T Cell Lymphotropic Virus Type 1, Human T Cell Lymphotropic Virus Type 2, and Hepatitis C Virus |
Authors: | CATERINO-DE-ARAUJO, Adele; MAGRI, Mariana Cavalheiro; SATO, Neuza Satomi; MORIMOTO, Helena Kaminami; BRIGIDO, Luis Fernando de Macedo; MORIMOTO, Arilson Akira |
Citation: | AIDS RESEARCH AND HUMAN RETROVIRUSES, v.30, n.1, p.97-101, 2014 |
Abstract: | HIV-1, human T cell lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) and hepatitis C virus (HCV) are common among intravenous drug users (IDUs) and can cause chronic infections in the host. Usually, the diagnosis of such viruses employs serological assays; however, some difficulties in confirming HTLV-2 infection have been reported in high-risk populations in Brazil. We present data of an unusual case of coinfection with HIV-1, HTLV-1, HTLV-2, and HCV in a male IDU in which HTLV-2 was detected only by molecular assays. Comparative analysis of retroviruses from 2002 and 2012 showed identical HTLV-1 and HTLV-2 sequences (LTR, env, and tax), and a change in HIV-1 tropism from CXCR4 to CCR5. No mutation was detected in the hot points of the env region of the HTLV-2 isolate that justified the lack of rgp46-II-specific antibodies. These data emphasize the need for molecular assays to diagnose HTLV-2 in high-risk populations in Brazil. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/47 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_MAGRI_Inability_to_Detect_Human_T_Cell_Lymphotropic_Virus_2014.PDF | publishedVersion (English) | 244.76 kB | Adobe PDF | View/Open |
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