Departamento de Patologia - FM/MPT
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High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 9.0
PLOS ONE, v.17, n.2, article ID e0262591, 14p, 2022
SARS-CoV-2 Nucleocapsid (N) is the most abundant viral protein expressed in host samples and is an important antigen for diagnosis. N is a 45 kDa protein that does not present disulfide bonds. Intending to avoid non-specific binding of SARS-CoV-2 N to antibodies from patients who previously had d...
Balanced spatial distribution of green areas creates healthier urban landscapes
JOURNAL OF APPLIED ECOLOGY, v.59, n.7, p.1884-1896, 2022
The benefits of green infrastructure on human well-being in urban areas are already well-established, with strong evidence of the positive effects of the amount and proximity to green areas. However, the understanding of how the spatial distribution and type of green areas affect health is still ...
Altered RNome expression in Murine Gastrocnemius Muscle following Exposure to Jararhagin, a Metalloproteinase from Bothrops jararaca Venom
TOXINS, v.14, n.7, article ID 472, 13p, 2022
Small RNAs (sRNAs) and microRNAs (miRNAs) are small endogenous noncoding single-stranded RNAs that regulate gene expression in eukaryotes. Experiments in mice and humans have revealed that a typical small RNA can affect the expression of a wide range of genes, implying that small RNAs function as...
Salivary, serological, and cellular immune response to the CoronaVac vaccine in health care workers with or without previous COVID-19
SCIENTIFIC REPORTS, v.12, n.1, article ID 10125, 12p, 2022
We investigated the anti-SARS-CoV-2 post-vaccine response through serum and salivary antibodies, serum antibody neutralizing activity and cellular immune response in samples from health care workers who were immunized with two doses of an inactivated virus-based vaccine (CoronaVac) who had or did...
Association Between GATA3 and Histopathological and Immunohistochemical Parameters in Early-Infiltrating Breast Carcinomas
EUROPEAN JOURNAL OF BREAST HEALTH, v.18, n.3, p.229-234, 2022
Objective: This study evaluated the frequency of GATA-binding protein 3 (GATA3) expression in early breast cancer and its relationship with histopathological and immunohistochemical parameters. Materials and Methods: GATA3 was analysed by immunohistochemistry in histological sections of rumors fr...
Association between Metabolic Disorders and Cholangiocarcinoma: Impact of a Postulated Risk Factor with Rising Incidence
CANCERS, v.14, n.14, article ID 3483, 14p, 2022
Simple Summary A potential relationship between cholangiocarcinoma and metabolic disorders has been suggested, but there is a lack of published data. This study aimed to describe the prevalence of metabolic disorders in a cohort of 122 patients with cholangiocarcinoma and report clinical outcomes...
Comparing dextrose prolotherapy with other substances in knee osteoarthritis pain relief: A systematic review
CLINICS, v.77, article ID 100037, 11p, 2022
The objective of this study is to compare the effectiveness of dextrose-prolotherapy with other substances for pain relief in patients with primary knee osteoarthritis. The literature screening was done in January 2021 through Medline (PubMed), EMBASE, and Database of the National Institute of He...
High levels of metals/metalloids in blood and urine of residents living in the area affected by the dam failing in Barra Longa, District, Brazil: A preliminary human biomonitoring study
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.83, article ID 103566, 5p, 2021
Fundao mining tailings dam in Mariana District has collapsed in 2015 and caused the biggest environmental disaster in Brazil. Barra Longa District had its urban area invaded by toxic sludge and its population was extensively exposed to it. Blood and urine samples were collected from 11 residents,...
Impact of Brazilian expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a multicenter study
ANNALS OF HEPATOLOGY, v.22, article ID 100294, 8p, 2021
Introduction and objectives: Hepatocellular carcinoma (HCC) is one of the main indications for orthotopic liver transplantation (OLT). In Brazil, selection criteria for HCC is an expanded version of the Milan Criteria (MC), the so-called Brazilian Milan Criteria(BMC). Our aims were to evaluate po...
Spatio-temporal network analysis of pig trade to inform the design of risk-based disease surveillance
PREVENTIVE VETERINARY MEDICINE, v.189, article ID 105314, 13p, 2021
Network analysis is a powerful tool to describe, estimate, and predict the role of pig trade in the spread of pathogens and generate essential patterns that can be used to understand, prevent, and mitigate possible outbreaks. This study aimed to describe the network between premises such as produ...