Coleções desta comunidade

Novos documentos depositados

1. Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression

   ANAIS BRASILEIROS DE DERMATOLOGIA, v.99, n.1, p.72-79, 2024

   Background: Methotrexate (MTX) is an alternative treatment for patients with moderate/severe atopic dermatitis (AD). Objective: The authors evaluated the effect of MTX on the cutaneous expression of cytokines and chemokines that are involved in the inflammatory response in adult AD patients who r...

2. Association of pulmonary black carbon accumulation with cardiac fibrosis in residents of Sao Paulo, Brazil

   ENVIRONMENTAL RESEARCH, v.248, article ID 118380, 8p, 2024

   Evidence suggests that myocardial interstitial fibrosis, resulting from cardiac remodeling, may possibly be influenced by mechanisms activated through the inhalation of airborne pollutants. However, limited studies have explored the relationship between lifetime exposure to carbon-based particles...

3. Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations

   GEROSCIENCE, v.46, n.2, Special Issue, p.2729-2738, 2024

   Several disturbances in T-cell mediated immunity have been described during aging, but immunosenescence of the B-cell compartment is less well elucidated. The peripheral blood B-cell compartment (CD19+) can be split into six main subpopulations according to the cell surface markers IgD, CD27, CD2...

4. Enhanced immunogenicity and protective efficacy in mice following a Zika DNA vaccine designed by modulation of membrane-anchoring regions and its association to adjuvants (vol 15, 1307546, 2024)

   FRONTIERS IN IMMUNOLOGY, v.15, article ID 1376059, 2p, 2024

5. Enhanced immunogenicity and protective efficacy in mice following a Zika DNA vaccine designed by modulation of membrane-anchoring regions and its association to adjuvants

   FRONTIERS IN IMMUNOLOGY, v.15, article ID 1307546, 12p, 2024

   Zika virus (ZIKV) is a re-emerging pathogen with high morbidity associated to congenital infection. Despite the scientific advances since the last outbreak in the Americas, there are no approved specific treatment or vaccines. As the development of an effective prophylactic approach remains unadd...

6. Outlining the skin-homing and circulating CLA<SUP>+</SUP>NK cells in patients with severe atopic dermatitis

   SCIENTIFIC REPORTS, v.14, n.1, article ID 2663, 9p, 2024

   Atopic dermatitis (AD) is a complex, multifactorial skin disease, characterized by pruritus and predominant Th2 inflammation. Innate immune cells may play a role in AD development and are composed of granulocytes, macrophages, innate-like T cells, and innate lymphoid cells. This study investigate...

7. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

   NATURE, v.616, n.7958, p.755-+, 2023

   Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis(1). These lesions are precursors for blood cancers(2-6), but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohor...

8. Synaptic Oligomers and Glial Cells in Alzheimer Disease

   JAMA NEUROLOGY, v.80, n.11, p.1136-1137, 2023

9. Small biopsies for pancreatic lesions: Is there still room for fine needle aspiration?

   CYTOPATHOLOGY, v.35, n.1, p.70-77, 2024

   Pancreatic carcinoma is an aggressive tumour with increasing incidence in both sexes worldwide. Early detection is, therefore, essential for patient management. A recent advancement involves the utilization of larger, thicker gauge needles, which enable the collection of core-type biopsies (FNB)....

10. Obituary Euphrosyne Setsu Umezawa

    LANCET INFECTIOUS DISEASES, v.24, n.1, p.20-20, 2024