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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCHAVES, Yuri Nogueira-
dc.contributor.authorTOREZAN, Luis Antonio-
dc.contributor.authorNIWA, Ane Beatriz Mautari-
dc.contributor.authorSANCHES JUNIOR, Jose Antonio-
dc.contributor.authorFESTA NETO, Ciro-
dc.date.accessioned2013-07-30T14:43:51Z-
dc.date.available2013-07-30T14:43:51Z-
dc.date.issued2012-
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.87, n.4, p.521-529, 2012-
dc.identifier.issn0365-0596-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/578-
dc.description.abstractPhotodynamic therapy involves administration of a photosensitizing drug and its subsequent activation by irradiation with a light source at wavelengths matching the absorption spectrum of the photosensitizer. In many countries around the world, topical photodynamic therapy has been approved for treatment of cutaneous oncologic conditions such as actinic keratosis, Bowen's disease, and superficial basal cell carcinoma. Multicenter, randomized, controlled studies have confirmed its efficacy and superior cosmetic outcomes compared to conventional therapies. Nevertheless, this therapeutic method presents some adverse effects, such as erythema, edema, pigmentation, pustules, and pain. There is no doubt that pain is the most severe of the adverse effects, being sometimes responsible for definitive treatment interruption. The pain mechanism has not yet been fully understood, which makes complete pain control a challenge to be conquered. In spite of that, this literature review presents some useful pain management strategies as well as the most important pain-related factors in photodynamic therapy.-
dc.description.abstractA terapia fotodinâmica consiste na administração de uma droga fotossensibilizante e sua subseqüente irradiação com uma fonte de luz de espectro correspondente ao do seu fotossensibilizador. Em diversos países do mundo, a terapia fotodinâmica tópica é aprovada para o tratamento de condições oncológicas cutâneas como queratoses actínicas, doença de Bowen e carcinoma basocelular superficial. Estudos multicêntricos controlados e randomizados confirmam sua eficácia e seus resultados cosméticos superiores em relação às terapias convencionais. No entanto, existem alguns efeitos adversos inerentes a esse método terapêutico, como eritema, edema, pigmentação, pústulas e dor. Essa última é, sem dúvida, a mais importante deles, chegando a ser responsável pela interrupção definitiva do tratamento em alguns casos. O mecanismo dessa dor permanece ainda não completamente entendido. Tal fato faz do controle total da dor durante a terapia fotodinâmica um desafio ainda a ser conquistado. Apesar disso, esta revisão apresenta algumas estratégias que podem ajudar os pacientes a tolerar melhor a terapia fotodinâmica, além de relacionar os principais fatores ligados à dor descritos na literatura.-
dc.language.isoeng-
dc.publisherSOC BRASILEIRA DERMATOLOGIA-
dc.relation.ispartofAnais Brasileiros de Dermatologia-
dc.rightsopenAccess-
dc.subjectPain, referred-
dc.subjectPhotochemotherapy-
dc.subjectPhotosensitizing agents-
dc.subjectAgentes fotossensibilizantes-
dc.subjectDor referida-
dc.subjectFotoquimioterapia-
dc.subject.othertopical 5-aminolevulinic acid-
dc.subject.otherrandomized controlled-trial-
dc.subject.otherfacial actinic keratoses-
dc.subject.otherlight-emitting-diodes-
dc.subject.otherbasal-cell carcinomas-
dc.subject.othercold-air analgesia-
dc.subject.otherdouble-blind-
dc.subject.otheraminolevulinic-acid-
dc.subject.othermethyl aminolevulinate-
dc.subject.otheracne-vulgaris-
dc.titlePain in photodynamic therapy: mechanism of action and management strategies-
dc.title.alternativeDor na terapia fotodinâmica: mecanismo de ação e estratégias de manejo-
dc.typearticle-
dc.rights.holderCopyright SOC BRASILEIRA DERMATOLOGIA-
dc.identifier.doi10.1590/S0365-05962012000400001-
dc.identifier.pmid22892763-
dc.subject.wosDermatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalNIWA, Ane Beatriz Mautari:Univ Sao Paulo, Sch Med, Dept Dermatol, Tumor Outpatient Clin, Sao Paulo, Brazil-
hcfmusp.description.beginpage521-
hcfmusp.description.endpage529-
hcfmusp.description.issue4-
hcfmusp.description.volume87-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84866375674-
hcfmusp.origem.idWOS:000307716200001-
hcfmusp.origem.idSCIELO:S0365-05962012000400001-
hcfmusp.publisher.cityRIO DE JANEIRO RJ-
hcfmusp.publisher.countryBRAZIL-
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dc.description.indexMEDLINE-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus34-
hcfmusp.scopus.lastupdate2022-05-20-
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Artigos e Materiais de Revistas Científicas - FM/MDT
Departamento de Dermatologia - FM/MDT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/53
LIM/53 - Laboratório de Micologia


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