Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/617
Title: Hepatitis B virus genotypes from European origin explains the high endemicity found in some areas from southern Brazil
Authors: BERTOLINI, Dennis ArmandoGOMES-GOUVEA, Michele SoaresCARVALHO-MELLO, Isabel Maria Vicente Guedes deSARACENI, Claudia PataraSITNIK, RobertaGRAZZIOTIN, Felipe GobbiLAURINDO, Jomar PereiraFAGUNDES, Nelson Jurandi RosaCARRILHO, Flair JosePINHO, Joao Renato Rebello
Citation: INFECTION GENETICS AND EVOLUTION, v.12, n.6, p.1295-1304, 2012
Abstract: Southern Brazil is considered an area of low Hepatitis B endemicity, but some areas of higher endemicity have been described in the Southwest of Parana and Santa Catarina states. The aim of this study was to evaluate viral genotypes circulating throughout Parana state. PCR amplification and partial sequencing of the S gene was carried out in 228 samples from HBsAg positive candidate blood donors. Samples have been collected in seven different counties (Cascavel, Curitiba, Foz do Iguacu, Francisco Beltrao, Matinga Londrina and Paranagua). The most common HBV genotype in Parana state was D (82.9%; 189/228), followed by A (14.1%; 32/228). Genotypes F (1.3%; 3/228), C (1.3%; 3/228) and H (0.4%; 1/228) were also found. Distribution of genotypes was different in the studied counties, but genotype D was the most frequent in all of them. In Francisco Beltrao, all studied samples belonged to genotype D. The high prevalence of HBV genotype Din South of Brazil is explained by the intense migration of settlers from Europeans countries. Subgenotypes A1 and A2 were identified circulating in all cities where HBV/A was found. As observed in other areas of Brazil, HBV/A1 is more frequent than the HBV/A2 in Parana state and its presence was significantly larger in black and mulatto individuals. Genotype C was found only in individuals with Asian ancestry from Londrina and Maringa. Most HBV/F sequences identified in this study were classified as subgenotype F2a that was previously described in Brazil. The sole case of subgenotype F4 was from Foz do Iguacu city, near to Northern Argentina, where F4 is highly prevalent. The single genotype H sample was from Curitiba. This is the first case of this genotype described in Brazil. Further studies should be carried out to determine if more genotype H samples can be found in other populations from Brazil.
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