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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSIQUEIRA, E. R. F.-
dc.contributor.authorOLIVEIRA, C. P. M. S.-
dc.contributor.authorCORREA-GIANNELLA, M. L.-
dc.contributor.authorSTEFANO, J. T.-
dc.contributor.authorCAVALEIRO, A. M.-
dc.contributor.authorFORTES, M. A. H. Z.-
dc.contributor.authorMUNIZ, M. T. C.-
dc.contributor.authorSILVA, F. S.-
dc.contributor.authorPEREIRA, L. M. M. B.-
dc.contributor.authorCARRILHO, F. J.-
dc.date.accessioned2013-07-30T14:47:57Z-
dc.date.available2013-07-30T14:47:57Z-
dc.date.issued2012-
dc.identifier.citationBRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.45, n.1, p.72-77, 2012-
dc.identifier.issn0100-879X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/640-
dc.description.abstractThe reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson's disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients.-
dc.description.sponsorshipCAPES-
dc.language.isoeng-
dc.publisherASSOC BRAS DIVULG CIENTIFICA-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
dc.rightsopenAccess-
dc.subjectHepatitis C-
dc.subjectSteatosis-
dc.subjectFibrosis-
dc.subjectMicrosomal transfer protein-
dc.subject.othertriglyceride transfer protein-
dc.subject.otherdensity-lipoprotein receptor-
dc.subject.otherfatty liver-disease-
dc.subject.othervirus core protein-
dc.subject.otherinsulin-resistance-
dc.subject.otheroxidative stress-
dc.subject.otherlipid droplet-
dc.subject.othergenotype-
dc.subject.otherpathogenesis-
dc.subject.otherhepatocytes-
dc.titleMTP-493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients-
dc.typearticle-
dc.rights.holderCopyright ASSOC BRAS DIVULG CIENTIFICA-
dc.identifier.doi10.1590/S0100-879X2011007500160-
dc.identifier.pmid22147193-
dc.subject.wosBiology-
dc.subject.wosMedicine, Research & Experimental-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalMUNIZ, M. T. C.:Univ Pernambuco, Dept Bioquim, Fac Med, Recife, PE, Brazil-
hcfmusp.author.externalSILVA, F. S.:Univ Pernambuco, Dept Bioquim, Fac Med, Recife, PE, Brazil-
hcfmusp.author.externalPEREIRA, L. M. M. B.:Univ Pernambuco, Dept Gastroenterol, Fac Med, Recife, PE, Brazil; Inst Figado Pernambuco, Recife, PE, Brazil-
hcfmusp.description.beginpage72-
hcfmusp.description.endpage77-
hcfmusp.description.issue1-
hcfmusp.description.volume45-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84855872703-
hcfmusp.origem.idWOS:000299053200012-
hcfmusp.origem.idSCIELO:S0100-879X2012000100012-
hcfmusp.publisher.citySAO PAULO-
hcfmusp.publisher.countryBRAZIL-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus13-
hcfmusp.scopus.lastupdate2024-02-23-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Artigos e Materiais de Revistas Científicas - LIM/25
LIM/25 - Laboratório de Endocrinologia Celular e Molecular


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