Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/640
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SIQUEIRA, E. R. F. | - |
dc.contributor.author | OLIVEIRA, C. P. M. S. | - |
dc.contributor.author | CORREA-GIANNELLA, M. L. | - |
dc.contributor.author | STEFANO, J. T. | - |
dc.contributor.author | CAVALEIRO, A. M. | - |
dc.contributor.author | FORTES, M. A. H. Z. | - |
dc.contributor.author | MUNIZ, M. T. C. | - |
dc.contributor.author | SILVA, F. S. | - |
dc.contributor.author | PEREIRA, L. M. M. B. | - |
dc.contributor.author | CARRILHO, F. J. | - |
dc.date.accessioned | 2013-07-30T14:47:57Z | - |
dc.date.available | 2013-07-30T14:47:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.45, n.1, p.72-77, 2012 | - |
dc.identifier.issn | 0100-879X | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/640 | - |
dc.description.abstract | The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson's disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients. | - |
dc.description.sponsorship | CAPES | - |
dc.language.iso | eng | - |
dc.publisher | ASSOC BRAS DIVULG CIENTIFICA | - |
dc.relation.ispartof | Brazilian Journal of Medical and Biological Research | - |
dc.rights | openAccess | - |
dc.subject | Hepatitis C | - |
dc.subject | Steatosis | - |
dc.subject | Fibrosis | - |
dc.subject | Microsomal transfer protein | - |
dc.subject.other | triglyceride transfer protein | - |
dc.subject.other | density-lipoprotein receptor | - |
dc.subject.other | fatty liver-disease | - |
dc.subject.other | virus core protein | - |
dc.subject.other | insulin-resistance | - |
dc.subject.other | oxidative stress | - |
dc.subject.other | lipid droplet | - |
dc.subject.other | genotype | - |
dc.subject.other | pathogenesis | - |
dc.subject.other | hepatocytes | - |
dc.title | MTP-493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients | - |
dc.type | article | - |
dc.rights.holder | Copyright ASSOC BRAS DIVULG CIENTIFICA | - |
dc.identifier.doi | 10.1590/S0100-879X2011007500160 | - |
dc.identifier.pmid | 22147193 | - |
dc.subject.wos | Biology | - |
dc.subject.wos | Medicine, Research & Experimental | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | MUNIZ, M. T. C.:Univ Pernambuco, Dept Bioquim, Fac Med, Recife, PE, Brazil | - |
hcfmusp.author.external | SILVA, F. S.:Univ Pernambuco, Dept Bioquim, Fac Med, Recife, PE, Brazil | - |
hcfmusp.author.external | PEREIRA, L. M. M. B.:Univ Pernambuco, Dept Gastroenterol, Fac Med, Recife, PE, Brazil; Inst Figado Pernambuco, Recife, PE, Brazil | - |
hcfmusp.description.beginpage | 72 | - |
hcfmusp.description.endpage | 77 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 45 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84855872703 | - |
hcfmusp.origem.id | WOS:000299053200012 | - |
hcfmusp.origem.id | SCIELO:S0100-879X2012000100012 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
hcfmusp.relation.reference | Adinolfi LE, 2001, HEPATOLOGY, V33, P1358, DOI 10.1053/jhep.2001.24432 | - |
hcfmusp.relation.reference | Agnello V, 1999, P NATL ACAD SCI USA, V96, P12766, DOI 10.1073/pnas.96.22.12766 | - |
hcfmusp.relation.reference | ALTER MJ, 1995, SEMIN LIVER DIS, V15, P5, DOI 10.1055/s-2007-1007259 | - |
hcfmusp.relation.reference | Andre P, 2002, J VIROL, V76, P6919, DOI 10.1128/JVI.76.14.6919-6928.2002 | - |
hcfmusp.relation.reference | Asselah T, 2003, GUT, V52, P1638, DOI 10.1136/gut.52.11.1638 | - |
hcfmusp.relation.reference | Asselah T, 2006, GUT, V55, P123, DOI 10.1136/gut.2005.069757 | - |
hcfmusp.relation.reference | Bernard S, 2000, DIABETOLOGIA, V43, P995, DOI 10.1007/s001250051481 | - |
hcfmusp.relation.reference | Boren J, 1998, J CLIN INVEST, V101, P1197, DOI 10.1172/JCI1785 | - |
hcfmusp.relation.reference | Boulant S, 2008, TRAFFIC, V9, P1268, DOI 10.1111/j.1600-0854.2008.00767.x | - |
hcfmusp.relation.reference | Clement S, 2009, VIRUSES-BASEL, V1, P126, DOI 10.3390/v1020126 | - |
hcfmusp.relation.reference | Corey KE, 2009, HEPATOLOGY, V50, P1030, DOI 10.1002/hep.23219 | - |
hcfmusp.relation.reference | Domitrovich AM, 2005, J BIOL CHEM, V280, P39802, DOI 10.1074/jbc.M510391200 | - |
hcfmusp.relation.reference | FRIEDEWA.WT, 1972, CLIN CHEM, V18, P499 | - |
hcfmusp.relation.reference | Gambino R, 2007, HEPATOLOGY, V45, P1097, DOI 10.1002/hep.21631 | - |
hcfmusp.relation.reference | GROBHOLZ R, 1993, CANCER RES, V53, P4204 | - |
hcfmusp.relation.reference | Guo JS, 2007, SEMIN LIVER DIS, V27, P413, DOI 10.1055/s-2007-991517 | - |
hcfmusp.relation.reference | Hui JM, 2002, J GASTROEN HEPATOL, V17, P873, DOI 10.1046/j.1440-1746.2002.02813.x | - |
hcfmusp.relation.reference | Karpe F, 1998, ARTERIOSCL THROM VAS, V18, P756 | - |
hcfmusp.relation.reference | Kumar D, 2002, HEPATOLOGY, V36, P1266, DOI 10.1053/jhep.2002.36370 | - |
hcfmusp.relation.reference | Mirandola S, 2009, LIVER INT, V29, P557, DOI 10.1111/j.1478-3231.2008.01892.x | - |
hcfmusp.relation.reference | Mirandola S, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-13 | - |
hcfmusp.relation.reference | Miyanari Y, 2007, NAT CELL BIOL, V9, P1089, DOI 10.1038/ncb1631 | - |
hcfmusp.relation.reference | Molina S, 2007, J HEPATOL, V46, P411, DOI 10.1016/j.jhep.2006.09.024 | - |
hcfmusp.relation.reference | Moradpour D, 2005, EUR J GASTROEN HEPAT, V17, P477, DOI 10.1097/00042737-200505000-00002 | - |
hcfmusp.relation.reference | Namikawa C, 2004, J HEPATOL, V40, P781, DOI 10.1016/j.jhep.2004.01.028 | - |
hcfmusp.relation.reference | Negro F, 2010, GUT, V59, P1279, DOI 10.1136/gut.2009.192732 | - |
hcfmusp.relation.reference | Nielsen LB, 1998, CIRCULATION, V98, P13 | - |
hcfmusp.relation.reference | Okuda M, 2002, GASTROENTEROLOGY, V122, P366, DOI 10.1053/gast.2002.30983 | - |
hcfmusp.relation.reference | Petit JM, 2006, MOL GENET METAB, V88, P196, DOI 10.1016/j.ymgme.2005.12.006 | - |
hcfmusp.relation.reference | Poynard T, 2003, HEPATOLOGY, V38, P75, DOI 10.1053/jhep.2003.50267 | - |
hcfmusp.relation.reference | Richardson MM, 2005, J MED GENET, V42, DOI 10.1136/jmg.2005.032557 | - |
hcfmusp.relation.reference | Romero-Gomez M, 2003, AM J GASTROENTEROL, V98, P1135, DOI 10.1016/S0002-9270(03)00185-0 | - |
hcfmusp.relation.reference | Rubbia-Brandt L, 2004, GUT, V53, P406, DOI 10.1136/gut.2003.018770 | - |
hcfmusp.relation.reference | Rubbia-Brandt L, 2000, J HEPATOL, V33, P106, DOI 10.1016/S0168-8278(00)80166-X | - |
hcfmusp.relation.reference | Farias de Azevedo Salgado Ana Lucia, 2010, Arquivos de Gastroenterologia, V47, P165 | - |
hcfmusp.relation.reference | Schreuder TCMA, 2008, WORLD J GASTROENTERO, V14, P2474, DOI 10.3748/wjg.14.2474 | - |
hcfmusp.relation.reference | Shi ST, 2002, VIROLOGY, V292, P198, DOI 10.1006/viro.2001.1225 | - |
hcfmusp.relation.reference | Syed GH, 2010, TRENDS ENDOCRIN MET, V21, P33, DOI 10.1016/j.tem.2009.07.005 | - |
hcfmusp.relation.reference | Zampino R, 2008, J VIRAL HEPATITIS, V15, P740, DOI 10.1111/j.1365-2893.2008.00994.x | - |
hcfmusp.relation.reference | Zoulim F, 2003, REV MED VIROL, V13, P57, DOI 10.1002/rmv.371 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 13 | - |
hcfmusp.scopus.lastupdate | 2024-02-23 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/07 Artigos e Materiais de Revistas Científicas - LIM/25 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SIQUEIRA_MTP_493G_T_gene_polymorphism_is_associated_with_2012.PDF | publishedVersion (English) | 453.75 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.