Subtle Gray Matter Changes in Temporo-Parietal Cortex Associated with Cardiovascular Risk Factors

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP DE TOLEDO FERRAZ ALVES, Tania Correa FMUSP-HC
BUSATTO, Geraldo F. FMUSP-HC 2011
dc.identifier.citation JOURNAL OF ALZHEIMERS DISEASE, v.27, n.3, p.575-589, 2011
dc.identifier.issn 1387-2877
dc.description.abstract Vascular risk factors may play an important role in the pathophysiology of Alzheimer's disease (AD). While there is consistent evidence of gray matter (GM) abnormalities in earlier stages of AD, the presence of more subtle GM changes associated with vascular risk factors in the absence of clinically significant vascular events has been scarcely investigated. This study aimed to examine GM changes in elderly subjects with cardiovascular risk factors. We predicted that the presence of cardiovascular risk would be associated with GM abnormalities involving the temporal-parietal cortices and limbic structures. We recruited 248 dementia-free subjects, age range 66-75 years, from the population-based "Sao Paulo Ageing and Health Study", classified in accordance to their Framingham Coronary Heart Disease Risk (FCHDR) score to undergo an MRI scan. We performed an overall analysis of covariance, controlled to total GM and APOE4 status, to investigate the presence of regional GM abnormalities in association with FCHDR subgroups (high-risk, medium-risk, and low-risk), and followed by post hoc t-test. We also applied a co-relational design in order to investigate the presence of linear progression of the GM vulnerability in association with cardiovascular risk factor. Voxel-based morphometry showed that the presence of cardiovascular risk factors were associated with regional GM loss involving the temporal cortices bilaterally. Those results retained statistical significance after including APOE4 as a covariate of interest. We also observed that there was a negative correlation between FCHDR scores and rGM distribution in the parietal cortex. Subclinical cerebrovascular abnormalities involving GM loss may provide an important link between cardiovascular risk factors and AD.
dc.description.sponsorship · Wellcome Trust, UK [GR066133MA]
· FAPESP, Brazil [04/15336-5, 2004/12694-8]
· CNPQ-Brazil
dc.language.iso eng
dc.publisher IOS PRESS
dc.rights openAccess
dc.subject Alzheimer's disease; elderly; MRI; population-based; vascular risk factors
dc.title Subtle Gray Matter Changes in Temporo-Parietal Cortex Associated with Cardiovascular Risk Factors
dc.type article
dc.rights.holder Copyright IO PRESS LIM/21 LIM/23 LIM/39
dc.identifier.doi 10.3233/JAD-2011-110827
dc.identifier.pmid 21841245
dc.type.category original article
dc.type.version publishedVersion DE TOLEDO FERRAZ ALVES, Tania Correa:HC:LIM/21 SCAZUFCA, Marcia:HC:LIM/23 SQUARZONI, Paula:FM: DE SOUZA DURAN, Fabio Luiz:HC:LIM/21 TAMASHIRO-DURAN, Jaqueline Hatsuko:HC:LIM/21 VALLADA, Homero P.:FM:MPS WAJNGARTEN, Mauricio:HC:INCOR MENEZES, Paulo R.:FM:MPR BUSATTO, Geraldo F.:FM:MPS · ANDREI, Anna: Cardiological Institute, General Hospital of University of Sao Paulo Medical School 2-s2.0-82555184980 WOS:000297865800012 AMSTERDAM NETHERLANDS
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