Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/720
Title: The Differential Clinical Impact of Human Coronavirus Species in Children With Cystic Fibrosis
Authors: SILVA FILHO, Luiz Vicente Ribeiro Ferreira daZERBINATI, Rodrigo MelimTATENO, Adriana FumieBOAS, Lucy VilasALMEIDA, Marina Buarque deLEVI, Jose EduardoDREXLER, Jan FelixDROSTEN, ChristianPANNUTI, Claudio Sergio
Citation: JOURNAL OF INFECTIOUS DISEASES, v.206, n.3, p.384-388, 2012
Abstract: We investigated the clinical impact of human coronaviruses (HCoV) OC43, 229E, HKU1 and NL63 in pediatric patients with cystic fibrosis (CF) during routine and exacerbation visits. A total of 408 nasopharyngeal aspirate samples were obtained from 103 patients over a 1-year period. Samples positive for HCoV were submitted for nucleotide sequencing to determine the species. Nineteen samples (4.65%) were positive for HCoV, of which 8 were positive for NL63, 6 for OC43, 4 for HKU1, and 1 for 229E. Identification of HCoV was not associated with an increased rate of respiratory exacerbations, but NL63-positive patients had higher exacerbation rates than patients who were positive for other HCoV species.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - LIM/52

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