Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/7447
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSANTOS, Astrid Meireles-
dc.contributor.authorSCANAVACCA, Mauricio Ibrahim-
dc.contributor.authorDARRIEUX, Francisco-
dc.contributor.authorIANNI, Barbara-
dc.contributor.authorMELO, Sissy Lara de-
dc.contributor.authorPISANI, Cristiano-
dc.contributor.authorNETO, Francisco Santos-
dc.contributor.authorSOSA, Eduardo-
dc.contributor.authorHACHUL, Denise Tessariol-
dc.date.accessioned2014-09-30T14:38:54Z-
dc.date.available2014-09-30T14:38:54Z-
dc.date.issued2014-
dc.identifier.citationARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.102, n.6, p.579-587, 2014-
dc.identifier.issn0066-782X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7447-
dc.description.abstractBackground: Sudden death is the leading cause of death in Chagas disease (CD), even in patients with preserved ejection fraction (EF), suggesting that destabilizing factors of the arrhythmogenic substrate (autonomic modulation) contribute to its occurrence. Objective: To determine baroreflex sensitivity (BRS) in patients with undetermined CD (GI), arrhythmogenic CD with nonsustained ventricular tachycardia (NSVT) (GII) and CD with spontaneous sustained ventricular tachycardia (STV) (GIII), to evaluate its association with the occurrence and complexity of arrhythmias. Method: Forty-two patients with CD underwent ECG and continuous and noninvasive BP monitoring (TASK force monitor). The following were determined: BRS (phenylephrine method); heart rate variability (HRV) on 24-h Holter; and EF (echocardiogram). Results: GIII had lower BRS (6.09 ms/mm Hg) as compared to GII (11.84) and GI (15.23). The difference was significant between GI and GIII (p = 0.01). Correlating BRS with the density of ventricular extrasystoles (VE), low VE density (<10/h) was associated with preserved BRS. Only 59% of the patients with high VE density (>10/h) had preserved BRS (p = 0.003). Patients with depressed BRS had higher VE density (p = 0.01), regardless of the EF. The BRS was the only variable related to the occurrence of SVT (p = 0.028). Conclusion: The BRS is preserved in undetermined CD. The BRS impairment increases as disease progresses, being more severe in patients with more complex ventricular arrhythmias. The degree of autonomic dysfunction did not correlate with EF, but with the density and complexity of ventricular arrhythmias.-
dc.language.isoeng-
dc.language.isopor-
dc.publisherARQUIVOS BRASILEIROS CARDIOLOGIA-
dc.relation.ispartofArquivos Brasileiros de Cardiologia-
dc.rightsopenAccess-
dc.subjectChagas Disease-
dc.subjectArrhythmias, Cardiac-
dc.subjectDeath, Sudden-
dc.subjectBaroreflex / physiology-
dc.subjectAnalysis of Variance-
dc.subject.othercardiac autonomic impairment-
dc.subject.otherheart-rate-variability-
dc.subject.otherventricular-tachycardia-
dc.subject.othermyocardial-infarction-
dc.subject.otherdeath-
dc.subject.othersudden-
dc.subject.othermortality-
dc.subject.otherhumans-
dc.subject.otherreflex-
dc.titleBaroreflex Sensitivity and its Association with Arrhythmic Events in Chagas Disease-
dc.typearticle-
dc.rights.holderCopyright ARQUIVOS BRASILEIROS CARDIOLOGIA-
dc.identifier.doi10.5935/abc.20140066-
dc.identifier.pmid25004420-
dc.subject.wosCardiac & Cardiovascular Systems-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSANTOS, Astrid Meireles:Inst Coracao HC FMUSP, Sao Paulo, Brazil-
hcfmusp.description.beginpage579-
hcfmusp.description.endpage587-
hcfmusp.description.issue6-
hcfmusp.description.volume102-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000339011700011-
hcfmusp.origem.id2-s2.0-84904202751-
hcfmusp.origem.idSCIELO:S0066-782X2014000600008-
hcfmusp.publisher.cityRIO DE JANEIRO-
hcfmusp.publisher.countryBRAZIL-
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dc.description.indexMEDLINE-
hcfmusp.citation.scopus2-
hcfmusp.scopus.lastupdate2022-05-20-
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Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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