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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorERKAN, Doruk-
dc.contributor.authorAGUIAR, Cassyanne L.-
dc.contributor.authorANDRADE, Danieli-
dc.contributor.authorCOHEN, Hannah-
dc.contributor.authorCUADRADO, Maria J.-
dc.contributor.authorDANOWSKI, Adriana-
dc.contributor.authorLEVY, Roger A.-
dc.contributor.authorORTEL, Thomas L.-
dc.contributor.authorRAHMAN, Anisur-
dc.contributor.authorSALMON, Jane E.-
dc.contributor.authorTEKTONIDOU, Maria G.-
dc.contributor.authorWILLIS, Rohan-
dc.contributor.authorLOCKSHIN, Michael D.-
dc.identifier.citationAUTOIMMUNITY REVIEWS, v.13, n.6, p.685-696, 2014-
dc.description.abstractAntiphospholipid Syndrome (APS) is characterized by vascular thrombosis and/or pregnancy morbidity occurring in patients with persistent antiphospholipid antibodies (aPL). The primary objective of the APS Treatment Trends Task Force, created as part of the 14th International Congress on aPL, was to systematically review the potential future treatment strategies for aPL-positive patients. The task force chose as future clinical research directions: a) determining the necessity for controlled clinical trials in venous thromboembolism with the new oral direct thrombin or anti-factor Xa inhibitors pending the results of the ongoing rivaroxaban in APS (RAPS) trial, and designing controlled clinical trials in other forms of thrombotic APS; b) systematically analyzing the literature as well as aPL/APS registries, and creating specific registries for non-warfarin/heparin anticoagulants; c) increasing recruitment for an ongoing primary thrombosis prevention trial, and designing secondary thrombosis and pregnancy morbidity prevention trials with hydroxychloroquine; d) determining surrogate markers to select patients for statin trials; e) designing controlled studies with rituximab and other and-B-cell agents; f) designing mechanistic and clinical studies with eculizumab and other complement inhibitors; and g) chemically modifying peptide therapy to improve the half-life and minimize immunogenicity. The report also includes recommendations for clinicians who consider using these agents in difficult-to-manage aPL-positive patients.-
dc.description.sponsorshipArthritis Research UK-
dc.relation.ispartofAutoimmunity Reviews-
dc.subjectAntiphospholipid syndrome-
dc.subjectOral direct thrombin inhibitors-
dc.subjectComplement and B-cell inhibition-
dc.subjectPeptide therapy-
dc.subject.otherheparin-induced thrombocytopenia-
dc.subject.otherhemolytic-uremic syndrome-
dc.subject.otherparoxysmal-nocturnal hemoglobinuria-
dc.subject.othertissue factor expression-
dc.subject.otherreverses thrombogenic properties-
dc.subject.othercomplement inhibitor eculizumab-
dc.subject.otherendothelial-cell activation-
dc.title14th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.type.versionpublishedVersion-, Doruk:Weill Cornell Med Coll, Hosp Special Surg, New York, NY 10021 USA-, Cassyanne L.:Weill Cornell Med Coll, Hosp Special Surg, New York, NY 10021 USA-, Hannah:Univ Coll London Hosp NHS Fdn Trust, Dept Hematol, London, England; UCL, London, England-, Maria J.:Guys & St Thomas Fdn Trust, Lupus Unit, London, England-, Adriana:Hosp Fed Servidores Estado, Dept Rheumatol, Rio De Janeiro, Brazil-, Roger A.:Univ Estado Rio de Janeiro, Dept Rheumatol, BR-20550011 Rio De Janeiro, Brazil-, Thomas L.:Duke Univ, Med Ctr, Ctr Thrombosis & Hemostasis, Durham, NC USA-, Anisur:Univ Coll London Hosp NHS Fdn Trust, Dept Hematol, London, England; UCL, London, England-, Jane E.:Weill Cornell Med Coll, Hosp Special Surg, New York, NY 10021 USA-, Maria G.:Univ Athens, Sch Med, Dept Med 1, GR-11527 Athens, Greece-, Rohan:Univ Texas Med Branch, Div Rheumatol, Galveston, TX 77555 USA-, Michael D.:Weill Cornell Med Coll, Hosp Special Surg, New York, NY 10021 USA-
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