Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/787
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBOR-SENG-SHU, Edson-
dc.contributor.authorNOGUEIRA, Ricardo De Carvalho-
dc.contributor.authorFIGUEIREDO, Eberval G.-
dc.contributor.authorEVARISTO, Eli Faria-
dc.contributor.authorCONFORTO, Adriana Bastos-
dc.contributor.authorTEIXEIRA, Manoel Jacobsen-
dc.date.accessioned2013-07-30T15:08:22Z-
dc.date.available2013-07-30T15:08:22Z-
dc.date.issued2012-
dc.identifier.citationNEUROSURGICAL FOCUS, v.32, n.1, article ID E5, 6p, 2012-
dc.identifier.issn1092-0684-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/787-
dc.description.abstractObject. Sonothrombolysis has recently been considered an emerging modality for the treatment of stroke. The purpose of the present paper was to review randomized clinical studies concerning the effects of sonothrombolysis associated with tissue plasminogen activator (tPA) on acute ischemic stroke. Methods. Systematic searches for literature published between January 1996 and July 2011 were performed for studies regarding sonothrombolysis combined with tPA for acute ischemic stroke. Only randomized controlled trials were included. Data extraction was based on ultrasound variables, patient characteristics, and outcome variables (rate of intracranial hemorrhages and arterial recanalization). Results. Four trials were included in this study; 2 trials evaluated the effect of transcranial Doppler (TCD) ultrasonography on sonothrombolysis, and 2 addressed transcranial color-coded duplex (TCCD) ultrasonography. The frequency of ultrasound waves varied from 1.8 to 2 MHz. The duration of thrombus exposure to ultrasound energy ranged from 60 to 120 minutes. Sample sizes were small, recanalization was evaluated at different time points (60 and 120 minutes), and inclusion criteria were heterogeneous. Sonothrombolysis combined with tPA did not lead to an increase in symptomatic intracranial hemorrhagic complications. Two studies demonstrated that patients treated with ultrasound combined with tPA had statistically significant higher rates of recanalization than patients treated with tPA alone. Conclusions. Despite the heterogeneity and the limitations of the reviewed studies, there is evidence that sonothrombolysis associated with tPA is a safe procedure and results in an increased rate of recanalization in the setting of acute ischemic stroke when wave frequencies and energy intensities of diagnostic ultrasound systems are used. (http://thejns.org/doi/abs/10.3171/2011.10.FOCUS11251)-
dc.language.isoeng-
dc.publisherAMER ASSOC NEUROLOGICAL SURGEONS-
dc.relation.ispartofNeurosurgical Focus-
dc.rightsopenAccess-
dc.subjectsonothrombolysis-
dc.subjectstroke-
dc.subjecttranscranial color-coded duplex-
dc.subjecttranscranial Doppler ultrasonography-
dc.subject.otherultrasound-enhanced thrombolysis-
dc.subject.othertissue-plasminogen activator-
dc.subject.otherintravenous microbubbles-
dc.subject.othertranscranial ultrasound-
dc.subject.otherclot lysis-
dc.subject.otherhemorrhage-
dc.subject.othersafety-
dc.subject.otherrecanalization-
dc.subject.othermetaanalysis-
dc.subject.othersonography-
dc.titleSonothrombolysis for acute ischemic stroke: a systematic review of randomized controlled trials-
dc.typearticle-
dc.rights.holderCopyright AMER ASSOC NEUROLOGICAL SURGEONS-
dc.identifier.doi10.3171/2011.10.FOCUS11251-
dc.identifier.pmid22208898-
dc.subject.wosClinical Neurology-
dc.subject.wosSurgery-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.description.articlenumberE5-
hcfmusp.description.issue1-
hcfmusp.description.volume32-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000298637800006-
hcfmusp.origem.id2-s2.0-84859758577-
hcfmusp.publisher.cityROLLING MEADOWS-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus27-
hcfmusp.scopus.lastupdate2024-03-08-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/15
LIM/15 - Laboratório de Investigação em Neurologia

Artigos e Materiais de Revistas Científicas - LIM/26
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental


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