Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/819
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCURI, Daniella D. G.-
dc.contributor.authorFONSECA, Angela Maggio-
dc.contributor.authorMARCONDES, Jose Antonio M.-
dc.contributor.authorALMEIDA, Jose Alcione M.-
dc.contributor.authorBAGNOLI, Vicente R.-
dc.contributor.authorSOARES- JR., Jose Maria-
dc.contributor.authorBARACAT, Edmund Chada-
dc.date.accessioned2013-07-30T15:09:00Z-
dc.date.available2013-07-30T15:09:00Z-
dc.date.issued2012-
dc.identifier.citationGYNECOLOGICAL ENDOCRINOLOGY, v.28, n.3, p.182-185, 2012-
dc.identifier.issn0951-3590-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/819-
dc.description.abstractObjective: To compare the efficacy of metformin with that of lifestyle changes in patients with polycystic ovary syndrome (PCOS). Design: Prospective, randomized clinical trial of 40 women with PCOS to analyze the effects of metformin and lifestyle intervention treatments on menstrual pattern and hormone and metabolic profile. The duration of treatment was 6 months. Statistical analysis was done using Student's t-test. Results: Fifteen women in the metformin group and 12 in the lifestyle changes group completed the study. The menstrual pattern improved by similar to 67% in both groups. There was a significant decrease in waist circumference in the lifestyle changes group (101.8 +/- 3.9 and 95.1 +/- 3.6, at baseline and at 6 months of treatment, respectively; p<0.001) and in body mass index (BMI) in both groups. The predictor of menstrual pattern improvement was BMI. Conclusions: Both metformin and lifestyle changes may increase the number of menstrual cycles in PCOS. This effect was related to a decrease in BMI.-
dc.language.isoeng-
dc.publisherINFORMA HEALTHCARE-
dc.relation.ispartofGynecological Endocrinology-
dc.rightsrestrictedAccess-
dc.subjectBMI-
dc.subjectlifestyle-
dc.subjectmenstrual cycle-
dc.subjectmetformin-
dc.subjectpolycystic ovary syndrome-
dc.subject.otherinsulin sensitivity-
dc.subject.otheroverweight women-
dc.subject.otherblood-pressure-
dc.subject.otherobese-patients-
dc.subject.otherdouble-blind-
dc.subject.otherweight-loss-
dc.subject.otherresistance-
dc.subject.otherprevalence-
dc.subject.othertherapy-
dc.subject.othertrial-
dc.titleMetformin versus lifestyle changes in treating women with polycystic ovary syndrome-
dc.typearticle-
dc.rights.holderCopyright INFORMA HEALTHCARE-
dc.identifier.doi10.3109/09513590.2011.583957-
dc.identifier.pmid22309675-
dc.subject.wosEndocrinology & Metabolism-
dc.subject.wosObstetrics & Gynecology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSOARES- JR., Jose Maria:Univ Fed Sao Paulo, Dept Gynecol, BR-04021051 Sao Paulo, Brazil-
hcfmusp.description.beginpage182-
hcfmusp.description.endpage185-
hcfmusp.description.issue3-
hcfmusp.description.volume28-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000300436700006-
hcfmusp.origem.id2-s2.0-84856880680-
hcfmusp.publisher.cityNEW YORK-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus35-
hcfmusp.scopus.lastupdate2022-05-20-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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