Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/821
Title: Evaluation of frozen-section analysis of surgical margins in the treatment of breast cancer
Authors: NOVITA, G.FILASSI, J. R.RUIZ, C. A.RICCI, M. D.PINCERATO, K. M.OLIVEIRA FILHO, H. R. deSOARES JR., J. M.BARACAT, E. C.
Citation: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, v.33, n.5, p.498-501, 2012
Abstract: Objective: To evaluate surgical margins in cases of ductal carcinoma through a histopathological exam using frozen sections. Materials and Methods: Retrospective study encompassing 242 conservative surgeries, 179 of which included intraoperative frozensection histopathology and 63 intraoperative nonfreezing techniques (macroscopy/gross examination and cytology). The results of such analyses were compared with those of the histology processing following paraffin embedment and hematoxylin and eosin (H & E) staining. A margin was deemed free when the distance between the tumor and the surgical border was equal to or greater than two millimeters. The factors given consideration for possibly affecting the results were: age, surgical aspects (skin removal and widening of surgical margins), histopathological findings (size, affected lymph nodes, and angiolymphatic invasion), and extensive intraductal and immunohistochemical components (estrogen, progesterone, Ki-67, and HER-2 receptors). In the statistical analyses, the chi-square test was used and negative predictive values were calculated. Results: The negative predictive values were 87.1% and 79.3% for frozen and nonfrozen sections, respectively. There was no significant difference between the two groups (p = 0.14). The factors under consideration had no influence on the results of the intraoperative exam of the margins. Conclusion: The present study allowed to conclude that the intraoperative exam of the surgical margins by frozen section is not superior to a macroscopy and / or cytology exam.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/58

Files in This Item:
File Description SizeFormat 
art_NOVITA_Evaluation_of_frozen_section_analysis_of_surgical_margins_2012.PDF
  Restricted Access
publishedVersion (English)162.42 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.