Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/8453
Title: Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
Authors: NACIF, Lucas SoutoANDRAUS, WellingtonKUBRUSLY, Marcia SaldanhaKUBRUSLY, Flavia SaldanhaGEBARA, Vera Cristina Bugelli CainelliISHIZAWA, AndreaD'ALBUQUERQUE, Luiz Augusto Carneiro
Citation: ACTA CIRURGICA BRASILEIRA, v.29, n.9, p.573-578, 2014
Abstract: PURPOSE: To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome. METHODS: A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software (R). Differences were considered statistically significant when p<0.05. RESULTS: Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05). CONCLUSION: Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.
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Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/37
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado


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