Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GAESTER, Karen FMUSP-HC
FONSECA, Luiz A. M. FMUSP-HC
LUIZ, Olinda FMUSP-HC
ASSONE, Tatiane FMUSP-HC
FONTES, Adriele Souza FMUSP-HC
COSTA, Fernando
DUARTE, Alberto J. S. FMUSP-HC
CASSEB, Jorge FMUSP-HC
dc.date.issued 2014
dc.identifier.citation SCIENTIFIC REPORTS, v.4, article ID 6592, 5p, 2014
dc.identifier.issn 2045-2322
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/8627
dc.description.abstract Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk for HPV-related diseases. The mean of this study is to determine the prevalence ofHPV in the oral tract of HIV-1-positive male subjects and its association with risk factors. A total of 283 oral wash samples from HIV-1-positive men were tested. The oral fluid samples were used for DNA extraction and conventional PCR amplification; HPV genotyping was performed by hybridization. HPV genotyping revealed that nine samples (3.5%) were positive for HPV DNA; the major high-risk HPV types identified were 51 and 66. Worldwide studies have shown a variable prevalence of oral HPV. The diversity of genotypes and the high prevalence of multiple infections in HIV-infected subjects can be better explained by the effects of HIV-induced immunosuppression. The most important risk factors are unprotected sexual intercourse, but other factors for this infection have been described elsewhere including smoking, age and HIV-positive serostatus. In this study, smoking was the most important risk factor for acquiring oral HPV in HIV-1-infected subjects in Brazil.
dc.description.sponsorship · Fapesp [2010/07076-4, 2011/16094-9]
dc.language.iso eng
dc.publisher NATURE PUBLISHING GROUP
dc.relation.ispartof Scientific Reports
dc.rights openAccess
dc.subject.other cervical-cancer; hpv infection; hiv; individuals; virus; women
dc.title Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors
dc.type article
dc.rights.holder Copyright NATURE PUBLISHING GROUP
dc.description.group LIM/38
dc.description.group LIM/56
dc.identifier.doi 10.1038/srep06592
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author GAESTER, Karen:IMT:
hcfmusp.author FONSECA, Luiz A. M.:HC:LIM/38
hcfmusp.author LUIZ, Olinda:HC:LIM/38
hcfmusp.author ASSONE, Tatiane:IMT:
hcfmusp.author FONTES, Adriele Souza:IMT:
hcfmusp.author DUARTE, Alberto J. S.:FM:MPT
hcfmusp.author CASSEB, Jorge:IMT:IMT
hcfmusp.author.external · COSTA, Fernando:Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, Sao Paulo, Brazil; Inst Trop Med, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84946122791
hcfmusp.origem.id WOS:000343293600001
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 11
hcfmusp.citation.wos 11
hcfmusp.affiliation.country Brasil


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