Acute physical exercise is safe in patients with primary antiphospholipid syndrome with exclusive venous thrombosis and under oral anticoagulation with warfarin

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GARCIA, Carolina Borges FMUSP-HC
SEGURO, Luciana Parente Costa FMUSP-HC
PERANDINI, Luiz Augusto FMUSP-HC
PINTO, Ana Lucia de Sa FMUSP-HC
LIMA, Fernanda Rodrigues FMUSP-HC
NEGRAO, Carlos Eduardo
BONFA, Eloisa FMUSP-HC
BORBA, Eduardo Ferreira FMUSP-HC
dc.date.issued 2014
dc.identifier.citation RHEUMATOLOGY INTERNATIONAL, v.34, n.12, p.1737-1741, 2014
dc.identifier.issn 0172-8172
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/8878
dc.description.abstract The purpose of present study was to evaluate the effects of maximal acute physical exercise on prothrombin time/international normalized ratio (PT/INR) in patients with primary antiphospholipid syndrome (PAPS) under oral anticoagulation with warfarin and the safety of acute exercise in regard to thrombosis and bleeding risk. Eighteen physically inactive women with PAPS (Sydney criteria) with exclusive venous events and without thrombocytopenia were included. All patients were under stable warfarin therapy (PT/INR target: 2.0-3.0). Eighteen age-matched healthy sedentary women without thrombosis/bleeding disorders were selected as controls. All subjects performed a maximal exercise test, and capillary blood samples were obtained pre-, post- and at 1-h post-exercise (recovery time) for PT/INR analysis using a portable CoaguCheck. PAPS patients and controls had similar mean age (31.50 +/- A 8.06 vs. 29.61 +/- A 7.05 years, p = 0.46) and body mass index (24.16 +/- A 3.67 vs. 24.66 +/- A 2.71 kg/m(2), p = 0.65). PAPS had a mild but significant increase in PT/INR value at 1-h post-exercise (recovery) compared with pre- (2.33 +/- A 0.34 vs. 2.26 +/- A 0.29, p = 0.001) and post-exercise (2.33 +/- A 0.34 vs. 2.26 +/- A 0.32, p = 0.001) that was observed in 61.11 % of these patients. None of the subjects had thrombotic or bleeding complications related to the acute exercise. Acute exercise in patients with PAPS with exclusive venous thrombosis was safe with a minor increase in PT/INR. This is an important step to introduce regular exercise training as a therapeutic tool in the management of these patients.
dc.language.iso eng
dc.publisher SPRINGER HEIDELBERG
dc.relation.ispartof Rheumatology International
dc.rights restrictedAccess
dc.subject Primary antiphospholipid syndrome; Exercise; Prothrombin time; Anticoagulation; Warfarin; Bleeding; Thrombosis
dc.subject.other fibrinolytic system; drugs; pharmacokinetics; coagulation; hemostasis; statement; therapy; disease; update
dc.title Acute physical exercise is safe in patients with primary antiphospholipid syndrome with exclusive venous thrombosis and under oral anticoagulation with warfarin
dc.type article
dc.rights.holder Copyright SPRINGER HEIDELBERG
dc.description.group LIM/17
dc.identifier.doi 10.1007/s00296-014-3038-7
dc.identifier.pmid 24825252
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author GARCIA, Carolina Borges:FM:
hcfmusp.author SEGURO, Luciana Parente Costa:HC:ICHC
hcfmusp.author PERANDINI, Luiz Augusto:HC:ICHC
hcfmusp.author PINTO, Ana Lucia de Sa:HC:LIM/17
hcfmusp.author LIMA, Fernanda Rodrigues:HC:LIM/17
hcfmusp.author BONFA, Eloisa:FM:MCM
hcfmusp.author BORBA, Eduardo Ferreira:FM:MCM
hcfmusp.author.external · NEGRAO, Carlos Eduardo:Univ Sao Paulo, Inst Heart, Sch Med, Unit Cardiovasc Rehabil & Exercise Physiol, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84939893396
hcfmusp.origem.id WOS:000345338700015
hcfmusp.publisher.city HEIDELBERG
hcfmusp.publisher.country GERMANY
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dc.description.index MEDLINE
dc.identifier.eissn 1437-160X
hcfmusp.citation.scopus 1
hcfmusp.citation.wos 1
hcfmusp.affiliation.country Brasil


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