Changes in Neuropsychological Tests and Brain Metabolism After Bariatric Surgery

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MARQUES, Emerson Leonildo FMUSP-HC
HALPERN, Alfredo FMUSP-HC
MANCINI, Marcio Correa FMUSP-HC
MELO, Maria Edna de FMUSP-HC
HORIE, Ndia Celeste FMUSP-HC
BUCHPIGUEL, Carlos Alberto FMUSP-HC
COUTINHO, Artur Martins Novaes FMUSP-HC
ONO, Carla Rachel FMUSP-HC
PRANDO, Silvana FMUSP-HC
SANTO, Marco Aurelio FMUSP-HC
CUNHA-NETO, Edecio FMUSP-HC
FUENTES, Daniel FMUSP-HC
CERCATO, Cintia FMUSP-HC
dc.date.issued 2014
dc.identifier.citation JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.99, n.11, p.E2347-E2352, 2014
dc.identifier.issn 0021-972X
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/8947
dc.description.abstract Context: The mechanisms by which obesity alters the cerebral function and the effect of weight loss on the brain have not been completely clarified. Objective: The objective of the study was to assess the effect of bariatric surgery on the cognitive function and cerebral metabolism. Design: Seventeen obese women were studied prior to and 24 weeks after bariatric surgery using neuropsychological tests and positron emission tomography. Setting: The study was conducted in a reference center for the treatment of obesity of a Brazilian public university. Participants: Thirty-three women paired by age and level of education made up two groups: 17 severely obese patients and 16 lean patients. They did not have diabetes mellitus or a family history of dementia. Main Outcome Measures: Comparison of performance in neuropsychological tests and cerebral metabolism of the obese women before and after bariatric surgery was measured. The results found at the two moments were compared with those of the women of normal weight. Results: Women with a mean age of 40.5 years and mean body mass index of 50.1 kg/m(2) when compared with women with mean body mass index of 22.3 kg/m(2) showed increased cerebral metabolism, especially in the posterior cingulate gyrus (P <.004). No difference was found between the groups for the neuropsychological tests. After 24 weeks the cerebral metabolism of the obese women was lower, similar to the lean women, and there was an improvement of executive function, accompanying changes of metabolic and inflammatory parameters. Conclusions: Obese women may have increased cerebral metabolism when compared with women of normal weight, and this appears to reverse after weight loss induced by bariatric surgery, accompanied by improved executive function.
dc.description.sponsorship · Brazilian National Council for Scientific and Technological Development-CNPq [472270/2011-7]
dc.language.iso eng
dc.publisher ENDOCRINE SOC
dc.relation.ispartof Journal of Clinical Endocrinology & Metabolism
dc.rights restrictedAccess
dc.subject.other mild cognitive impairment; gastric bypass-surgery; body-mass index; alzheimers-disease; insulin-resistance; reduction; women
dc.title Changes in Neuropsychological Tests and Brain Metabolism After Bariatric Surgery
dc.type article
dc.rights.holder Copyright ENDOCRINE SOC
dc.description.group LIM/18
dc.description.group LIM/43
dc.description.group LIM/19
dc.identifier.doi 10.1210/jc.2014-2068
dc.identifier.pmid 25157409
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MARQUES, Emerson Leonildo:FM:
hcfmusp.author HALPERN, Alfredo:HC:ICHC
hcfmusp.author MANCINI, Marcio Correa:HC:LIM/18
hcfmusp.author MELO, Maria Edna de:HC:LIM/18
hcfmusp.author HORIE, Ndia Celeste:FM:
hcfmusp.author BUCHPIGUEL, Carlos Alberto:FM:MDR
hcfmusp.author COUTINHO, Artur Martins Novaes:HC:ICESP
hcfmusp.author ONO, Carla Rachel:HC:LIM/43
hcfmusp.author PRANDO, Silvana:HC:LIM/43
hcfmusp.author SANTO, Marco Aurelio:FM:MGT
hcfmusp.author CUNHA-NETO, Edecio:FM:MCM
hcfmusp.author FUENTES, Daniel:HC:IPQ
hcfmusp.author CERCATO, Cintia:HC:ICHC
hcfmusp.origem.id 2-s2.0-84909996338
hcfmusp.origem.id WOS:000346743100079
hcfmusp.publisher.city WASHINGTON
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1945-7197
hcfmusp.citation.scopus 26
hcfmusp.citation.wos 23


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