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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | FONSECA, Fabricio Lopes da | - |
dc.contributor.author | LUNARDELLI, Patricia | - |
dc.contributor.author | MATAYOSHI, Suzana | - |
dc.date.accessioned | 2013-07-30T15:14:12Z | - |
dc.date.available | 2013-07-30T15:14:12Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | ARQUIVOS BRASILEIROS DE OFTALMOLOGIA, v.75, n.2, p.97-100, 2012 | - |
dc.identifier.issn | 0004-2749 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/897 | - |
dc.description.abstract | Purpose: To report the finding of nasolacrimal drainage system obstruction associated with radio iodine therapy and to review clinical data and the surgical treatment outcome of this rare complication. Methods: We retrospectively analyzed ophthalmological data of patients with history of thyroid carcinoma that underwent radioactive iodine I-131 therapy and were referred to lacrimal surgery. Results: 17 patients with thyroid cancer treated with thyroidectomy and radioactive iodine I-131 therapy presented symptomatic nasolacrimal duct obstruction after 13.2 months following cancer treatment. 11 patients presented bilateral epiphora, 8 had lacrimal sac mucocele. Age range was 30 to 80 years, 10 patients had less than or equal to 49 years. The mean cumulative dose of radioiodine was 571mCi (range: 200-1200 mCi). Nasal obstruction symptoms and increased salivary glands were also present in 53% of patients. All subjects underwent dacryocystorhinostomy. Dilation of the lacrimal sac and increased intraoperative bleeding was also observed in 3 younger patients. Complete epiphora and dacryocystitis resolution after surgery occurred in 82.4%, and partial in 17.6% (3 patients that still presented unilateral relapse after correction of bilateral obstruction). Mean follow-up was 6 months (range: 2-24 months). Conclusions: Cumulative high dose of radioidine, nasal and salivary gland dysfunction are associated with lacrimal drainage obstruction. We observed a great percentage of younger patients presenting dacryocystitis when compared to the idiopathic dacryostenosis. Radioactive iodine uptake by nasolacrimal duct mucosa with subsequent inflammation, edema and fibrosis seems to have a relationship to lacrimal duct obstruction. The knowledge of this complication is important for the study and proper management of these patients. | - |
dc.description.abstract | Objetivo: Descrever uma série de pacientes portadores de obstrução do sistema lacrimal associado à radioiodoterapia para tratamento de carcinoma de tireoide, revisar os dados clínicos e a resposta ao tratamento cirúrgico desta rara complicação. Métodos: Foi realizada uma análise retrospectiva dos achados oftalmológicos de pacientes com histórico de carcinoma de tireoide previamente submetidos à tireoidectomia e à RIT que foram encaminhados para cirurgia de vias lacrimais. Resultados: Dezessete pacientes com carcinoma de tireoide tratados com tireoidectomia e RIT apresentaram obstrução do ducto nasolacrimal sintomática após período médio de 13,2 meses do tratamento do câncer. Onze pacientes tiveram epífora bilateral, 8 com mucocele de saco lacrimal. A idade dos pacientes variou entre 30 e 80 anos, sendo 10 com idade menor ou igual a 49 anos. A dose cumulativa média de radioiodo administrada foi de 571 mCi (variação entre 200-1200 mCi). Sintomas de obstrução nasal e aumento de glândulas salivares ocorreram em 53% dos pacientes. Todos os pacientes foram submetidos à dacriocistorrinostomia. Observou-se ainda que nos 3 pacientes mais jovens houve maior sangramento intraoperatótio e dilatação de saco lacrimal. A resolução completa da epífora e da dacriocistite ocorreu em 82,4%, e foi parcial em 17,6% (3 pacientes mantiveram queixa unilateral após a correção da obstrução bilateralmente). O seguimento médio foi de 6 meses (intervalo: 2-24 meses). Conclusões: Alta dose cumulativa de radioiodo, disfunção nasal e de glândulas salivares estão associadas à obstrução das vias lacrimais. Observa-se uma maior porcentagem de pacientes mais jovens apresentando quadro de dacriocistite quando comparado à dacrioestenose idiopática. A absorção de iodo radioativo pela mucosa do ducto nasolacrimal com subsequente inflamação, edema e fibrose parece ter relação direta com a obstrução do ducto nasolacrimal. O conhecimento desta complicação é importante para o estudo e abordagem correta desses pacientes. | - |
dc.language.iso | por | - |
dc.publisher | CONSEL BRASIL OFTALMOLOGIA | - |
dc.relation.ispartof | Arquivos Brasileiros de Oftalmologia | - |
dc.rights | openAccess | - |
dc.subject | Nasolacrimal duct/radiation effects | - |
dc.subject | Lacrimal apparatus diseases | - |
dc.subject | Thyroid neoplasms/radiotherapy | - |
dc.subject | Iodine radioisotopes | - |
dc.subject | Ducto nasolacrimal/efeitos de radiação | - |
dc.subject | Doenças do aparelho lacrimal | - |
dc.subject | Neoplasias da glândula tireoide/radioterapia | - |
dc.subject | Radioisótopos de iodo | - |
dc.subject.other | dose radioiodine therapy | - |
dc.subject.other | i-131 therapy | - |
dc.subject.other | cancer | - |
dc.subject.other | salivary | - |
dc.subject.other | complications | - |
dc.subject.other | papillary | - |
dc.title | Obstrução de vias lacrimais associada ao tratamento radioiodoterápico de carcinoma de tireoide | - |
dc.title.alternative | Lacrimal drainage system obstruction associated to radioactive iodine therapy for thyroid carcinoma | - |
dc.type | article | - |
dc.rights.holder | Copyright CONSEL BRASIL OFTALMOLOGIA | - |
dc.identifier.doi | 10.1590/S0004-27492012000200005 | - |
dc.identifier.pmid | 22760799 | - |
dc.subject.wos | Ophthalmology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 97 | - |
hcfmusp.description.endpage | 100 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 75 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000310841600005 | - |
hcfmusp.origem.id | 2-s2.0-84867151317 | - |
hcfmusp.origem.id | SCIELO:S0004-27492012000200005 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
hcfmusp.relation.reference | Alexander C, 1998, J NUCL MED, V39, P1551 | - |
hcfmusp.relation.reference | ALLWEISS P, 1984, J NUCL MED, V25, P755 | - |
hcfmusp.relation.reference | Bohuslavizki KH, 1996, NUCL MED COMMUN, V17, P681, DOI 10.1097/00006231-199608000-00006 | - |
hcfmusp.relation.reference | Brito AD, 2011, CAD SAUDE PUBLICA, V27, P1441 | - |
hcfmusp.relation.reference | Burns JA, 2004, OPHTHAL PLAST RECONS, V20, P126, DOI 10.1097/01.IOP.0000117340.41819.81 | - |
hcfmusp.relation.reference | Davies L, 2006, JAMA-J AM MED ASSOC, V295, P2164, DOI 10.1001/jama.295.18.2164 | - |
hcfmusp.relation.reference | DIRUSSO G, 1994, SURGERY, V116, P1024 | - |
hcfmusp.relation.reference | Fard-Esfahani A, 2007, CLIN NUCL MED, V32, P696, DOI 10.1097/RLU.0b013e318124fdb6 | - |
hcfmusp.relation.reference | Ferlay J, 2010, IARC CANC BASE | - |
hcfmusp.relation.reference | Kloos RT, 2002, J CLIN ENDOCR METAB, V87, P5817, DOI 10.1210/jc.2002-020210 | - |
hcfmusp.relation.reference | LEDER O, 1982, HISTOCHEMISTRY, V74, P585, DOI 10.1007/BF00496673 | - |
hcfmusp.relation.reference | LEVENSON D, 1994, ANN INTERN MED, V120, P576 | - |
hcfmusp.relation.reference | MARKITZIU A, 1993, ORAL SURG ORAL MED O, V75, P318, DOI 10.1016/0030-4220(93)90144-S | - |
hcfmusp.relation.reference | Mazzaferri EL, 2001, J CLIN ENDOCR METAB, V86, P1447, DOI 10.1210/jc.86.4.1447 | - |
hcfmusp.relation.reference | SAMAAN NA, 1992, J CLIN ENDOCR METAB, V75, P714, DOI 10.1210/jc.75.3.714 | - |
hcfmusp.relation.reference | Schmid KE, 2006, SURV OPHTHALMOL, V51, P19, DOI 10.1016/j.survophthal.2005.11.001 | - |
hcfmusp.relation.reference | Shepler TR, 2003, OPHTHAL PLAST RECONS, V19, P479, DOI 10.1097/01.IOP.0000092802.75899.F8 | - |
hcfmusp.relation.reference | Solans R, 2001, J NUCL MED, V42, P738 | - |
dc.description.index | MEDLINE | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 17 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOF Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/33 |
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