Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorPASINI, Fatima Solange-
dc.contributor.authorZILBERSTEIN, Bruno-
dc.contributor.authorSNITCOVSKY, Igor-
dc.contributor.authorROELA, Rosimeire Aparecida-
dc.contributor.authorMANGONE, Flavia R. Rotea-
dc.contributor.authorRIBEIRO JR., Ulysses-
dc.contributor.authorNONOGAKI, Suely-
dc.contributor.authorBRITO, Glauber Costa-
dc.contributor.authorCALLEGARI, Giovanna D.-
dc.contributor.authorCECCONELLO, Ivan-
dc.contributor.authorALVES, Venancio Avancini Ferreira-
dc.contributor.authorELUF-NETO, Jose-
dc.contributor.authorCHAMMAS, Roger-
dc.contributor.authorFEDERICO, Miriam Hatsue Honda-
dc.identifier.citationJOURNAL OF GASTROENTEROLOGY, v.49, n.11, p.1453-1466, 2014-
dc.description.abstractThe TNM Classification of Malignant Tumours (TNM) staging system is the primary means of determining a prognosis for gastric adenocarcinoma (GC). However, tumor behavior in the individual patient is unpredictable and in spite of treatment advances, a classification of 'advanced stage' still portends a poor prognosis. Thus, further insights from molecular analyses are needed for better prognostic stratification and determination of new therapeutic targets. A total of fifty-one fresh frozen tumor samples from patients with histopathologically confirmed diagnoses of GC, submitted to surgery with curative intent, were included in the study. Total RNA was extracted from an initial group of fifteen samples matched for known prognostic factors, categorized into two subgroups, according to patient overall survival: poor (< 24 months) or favorable (at or above 24 months), and hybridized to Affymetrix Genechip human genome U133 plus 2.0 for genes associated with prognosis selection. Thirteen genes were selected for qPCR validation using those initial fifteen samples plus additional thirty-six samples. A total of 108 genes were associated with poor prognosis, independent of tumor staging. Using systems biology, we suggest that this panel reflects the dampening of immune/inflammatory response in the tumor microenvironment level and a shift to Th2/M2 activity. A gene trio (OLR1, CXCL11 and ADAMDEC1) was identified as an independent marker of prognosis, being the last two markers validated in an independent patient cohort. We determined a panel of three genes with prognostic value in gastric cancer, which should be further investigated. A gene expression profile suggestive of a dysfunctional inflammatory response was associated with unfavorable prognosis.-
dc.description.sponsorshipFundacao Faculdade de Medicina-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [577603/2008-6]-
dc.publisherSPRINGER JAPAN KK-
dc.relation.ispartofJournal of Gastroenterology-
dc.subjectBiomarkers of prognosis-
dc.subjectImmune response-
dc.subjectInflammatory response-
dc.subjectGastric cancer-
dc.subject.otherhelicobacter-pylori infection-
dc.titleA gene expression profile related to immune dampening in the tumor microenvironment is associated with poor prognosis in gastric adenocarcinoma-
dc.rights.holderCopyright SPRINGER JAPAN KK-
dc.subject.wosGastroenterology & Hepatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Suely:Adolfo Lutz Inst, Lab Imunohistoquim, Div Cent Patol, Sao Paulo, Brazil-
hcfmusp.relation.referenceAkaike H, 2007, ANTICANCER RES, V27, P449-
hcfmusp.relation.referenceAKAMA Y, 1995, JPN J CANCER RES, V86, P617-
hcfmusp.relation.referenceBang YJ, 2010, LANCET, V376, P687, DOI 10.1016/S0140-6736(10)61121-X-
hcfmusp.relation.referenceBates EEM, 2002, IMMUNOGENETICS, V54, P96, DOI 10.1007/s00251-002-0430-3-
hcfmusp.relation.referenceChen CN, 2005, J CLIN ONCOL, V23, P7286, DOI 10.1200/JCO.2004.00.2253-
hcfmusp.relation.referenceChen CN, 2004, CANCER LETT, V213, P73, DOI 10.1016/j.canlet.2004.05.020-
hcfmusp.relation.referenceCrew KD, 2006, WORLD J GASTROENTERO, V12, P354-
hcfmusp.relation.referenceDunn S, 2008, BIOCHEM J, V409, P349, DOI 10.1042/BJ20071196-
hcfmusp.relation.referenceFritsche J, 2003, IMMUNOLOGY, V110, P450, DOI 10.1046/j.1365-2567.2003.01754.x-
hcfmusp.relation.referenceHwang ES, 2009, EXP BIOL MED, V234, P105, DOI 10.3181/0806-RM-190-
hcfmusp.relation.referenceJhawer M, 2009, AM J CLIN ONCOL-CANC, V32, P356, DOI 10.1097/COC.0b013e31818c08e8-
hcfmusp.relation.referenceKondo T, 2006, CANCER SCI, V97, P780, DOI 10.1111/j.1349-7006.2006.00231.x-
hcfmusp.relation.referenceLaskin DL, 2009, CHEM RES TOXICOL, V22, P1376, DOI 10.1021/tx900086v-
hcfmusp.relation.referenceLeung SY, 2004, GASTROENTEROLOGY, V127, P457, DOI 10.1053/S0016-5085(04)00923-0-
hcfmusp.relation.referenceMA XC, 1994, ACTA ONCOL, V33, P187-
hcfmusp.relation.referenceMacartney-Coxson DP, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-187-
hcfmusp.relation.referenceMarchet A, 2007, ANN SURG ONCOL, V14, P1058, DOI 10.1245/s10434-006-9090-0-
hcfmusp.relation.referenceMcLean MH, 2011, RECENT RESULTS CANC, V185, P173, DOI 10.1007/978-3-642-03503-6_11-
hcfmusp.relation.referenceMehta JL, 2003, ARTERIOSCL THROM VAS, V23, P2203, DOI 10.1161/01.ATV.0000094411.98127.5F-
hcfmusp.relation.referenceMori M, 1997, NAT MED, V3, P593, DOI 10.1038/nm0697-593-
hcfmusp.relation.referenceMurata S, 1998, GASTRIC CANC, V1, P71-
hcfmusp.relation.referenceNOMURA A, 1991, NEW ENGL J MED, V325, P1132, DOI 10.1056/NEJM199110173251604-
hcfmusp.relation.referenceParkin DM, 2006, INT J CANCER, V118, P3030, DOI 10.1002/ijc.21731-
hcfmusp.relation.referencePARSONNET J, 1991, NEW ENGL J MED, V325, P1127, DOI 10.1056/NEJM199110173251603-
hcfmusp.relation.referencePeters CJ, 2010, GASTROENTEROLOGY, V139, P1995, DOI 10.1053/j.gastro.2010.05.080-
hcfmusp.relation.referencePfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45-
hcfmusp.relation.referenceQuiding-Jarbrink M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015018-
hcfmusp.relation.referenceSanz-Ortega J, 2000, HISTOL HISTOPATHOL, V15, P455-
hcfmusp.relation.referenceSawamura T, 1997, NATURE, V386, P73, DOI 10.1038/386073a0-
hcfmusp.relation.referenceShapiro SD, 2003, EUR RESPIR J, V22, P30-
hcfmusp.relation.referenceTanigawa N, 1997, J CLIN ONCOL, V15, P826-
hcfmusp.relation.referenceTeramoto K, 2005, J SURG RES, V124, P225, DOI 10.1016/j.jss.2004.10.003-
hcfmusp.relation.referenceVandesompele J, 2002, GENOME BIOL, V3-
hcfmusp.relation.referenceWang M, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-225-
hcfmusp.relation.referenceWang SK, 2007, WORLD J GASTROENTERO, V13, P2923-
hcfmusp.relation.referenceXu ZY, 2010, BIOMED PHARMACOTHER, V64, P133, DOI 10.1016/j.biopha.2009.06.021-
hcfmusp.relation.referenceYoshida H, 1998, BIOCHEM J, V334, P9-
hcfmusp.relation.referenceZheng Leizhen, 2004, Gastric Cancer, V7, P61-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MDR
Departamento de Radiologia - FM/MDR

Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - FM/MPR
Departamento de Medicina Preventiva - FM/MPR

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - LIM/35
LIM/35 - Laboratório de Nutrição e Cirurgia Metabólica do Aparelho Digestivo

Artigos e Materiais de Revistas Científicas - LIM/37
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado

Artigos e Materiais de Revistas Científicas - LIM/38
LIM/38 - Laboratório de Epidemiologia e Imunobiologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)3.04 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.