Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/926
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SOUZA, Paola da Costa | - |
dc.contributor.author | PARRA, Edwin Roger | - |
dc.contributor.author | ATANAZIO, Marcelo Junqueira | - |
dc.contributor.author | SILVA, Osmar Bianchi da | - |
dc.contributor.author | NOLETO, Gustavo Sousa | - |
dc.contributor.author | AB'SABER, Alexandre Muxfeldt | - |
dc.contributor.author | FERNEZLIAN, Sandra de Morais | - |
dc.contributor.author | TAKAGAKI, Tereza | - |
dc.contributor.author | CAPELOZZI, Vera Luiza | - |
dc.date.accessioned | 2013-07-30T15:14:51Z | - |
dc.date.available | 2013-07-30T15:14:51Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | HISTOPATHOLOGY, v.61, n.4, p.587-596, 2012 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/926 | - |
dc.description.abstract | Aims: Development of effective immune-based therapies for patients with non-small-cell lung carcinoma (NSCLC) depends on an accurate characterization of complex interactions that occur between immune cells and the tumour environment. Methods and results: Innate and adaptive immune responses were evaluated in relation to prognosis in 65 patients with surgically excised NSCLC. Immunohistochemistry and morphometry were used to determine the abundance and distribution of immune cells. We found low numbers of immune cells and levels of cytokines in the tumour environment when compared with surrounding parenchyma. Smoking was associated inversely with the adaptive immune response and directly with innate immunity. We observed a prominent adaptive immune response in squamous cell carcinomas (SCC) but greater innate immune responses in adenocarcinomas and large cell carcinomas. Cox model analysis showed a low risk of death for smoking <41 packs/year, N-0 tambour stage, squamous carcinoma, CD4(+) > 16.81% and macrophages/monocytes >4.5%. Collectively, the data indicate that in NSCLC there is not a substantive local immune cell infiltrate within the tumour. Conclusion: Although immune cell infiltration is limited in NSCLC it appears to have an impact on prognosis and this may be of relevance for new immunotherapeutic approaches. | - |
dc.description.sponsorship | National Council for Scientific and Technological Development (CNPq) | - |
dc.description.sponsorship | Foundation for the Support of Research of the State of Sao Paulo [FAPESP 07/56247-3, 07/58494-8] | - |
dc.description.sponsorship | Laboratories for Medical Research, Hospital das Clinicas, University of Sao Paulo Medical School [FMUSP-HC/LIMs] | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | Histopathology | - |
dc.rights | restrictedAccess | - |
dc.subject | cytokines | - |
dc.subject | immune cells | - |
dc.subject | interleukins | - |
dc.subject | lung cancer | - |
dc.subject.other | natural-killer-cells | - |
dc.subject.other | nucleolar organizer region | - |
dc.subject.other | immature dendritic cells | - |
dc.subject.other | tumor-necrosis-factor | - |
dc.subject.other | prognostic value | - |
dc.subject.other | morphometric evaluation | - |
dc.subject.other | t-lymphocytes | - |
dc.subject.other | lymph-nodes | - |
dc.subject.other | cancer | - |
dc.subject.other | survival | - |
dc.title | Different morphology, stage and treatment affect immune cell infiltration and long-term outcome in patients with non-small-cell lung carcinoma | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1111/j.1365-2559.2012.04318.x | - |
dc.identifier.pmid | 22716510 | - |
dc.subject.wos | Cell Biology | - |
dc.subject.wos | Pathology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ATANAZIO, Marcelo Junqueira:Univ Sao Paulo, Dept Patol, Fac Med, BR-01296903 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 587 | - |
hcfmusp.description.endpage | 596 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 61 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84871919242 | - |
hcfmusp.origem.id | WOS:000310481800006 | - |
hcfmusp.publisher.city | HOBOKEN | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Aloysius MM, 2006, SURG-J R COLL SURG E, V4, P195 | - |
hcfmusp.relation.reference | Al-Shibli K, 2009, HISTOPATHOLOGY, V55, P301, DOI 10.1111/j.1365-2559.2009.03379.x | - |
hcfmusp.relation.reference | Antonangelo L, 1997, CHEST, V111, P110, DOI 10.1378/chest.111.1.110 | - |
hcfmusp.relation.reference | Arenberg DA, 2000, CANCER IMMUNOL IMMUN, V49, P63, DOI 10.1007/s002620050603 | - |
hcfmusp.relation.reference | Baleeiro RB, 2008, CANCER IMMUNOL IMMUN, V57, P1335, DOI 10.1007/s00262-008-0468-7 | - |
hcfmusp.relation.reference | Banchereau J, 1998, NATURE, V392, P245, DOI 10.1038/32588 | - |
hcfmusp.relation.reference | BARBUTO JAM, 1995, CANCER IMMUNOL IMMUN, V40, P31, DOI 10.1007/BF01517233 | - |
hcfmusp.relation.reference | Bell D, 1999, J EXP MED, V190, P1417, DOI 10.1084/jem.190.10.1417 | - |
hcfmusp.relation.reference | BERNARDI FD, 1995, CHEST, V107, P614 | - |
hcfmusp.relation.reference | Bernardi FD, 1997, MODERN PATHOL, V10, P992 | - |
hcfmusp.relation.reference | Bingle L, 2002, J PATHOL, V196, P254, DOI 10.1002/path.1027 | - |
hcfmusp.relation.reference | Brambilla E, 2004, PATHOLOGY GENETICS T | - |
hcfmusp.relation.reference | Carvalho HA, 1997, HISTOPATHOLOGY, V31, P420, DOI 10.1046/j.1365-2559.1997.2940885.x | - |
hcfmusp.relation.reference | Chan CW, 2008, CELL DEATH DIFFER, V15, P58, DOI 10.1038/sj.cdd.4402235 | - |
hcfmusp.relation.reference | Chan CW, 2006, NAT MED, V12, P207, DOI 10.1038/nm1352 | - |
hcfmusp.relation.reference | Chaux P, 1996, LAB INVEST, V74, P975 | - |
hcfmusp.relation.reference | Coca S, 1997, CANCER, V79, P2320, DOI 10.1002/(SICI)1097-0142(19970615)79:12<2320::AID-CNCR5>3.0.CO;2-P | - |
hcfmusp.relation.reference | Coventry BJ, 2003, BRIT J CANCER, V89, P533, DOI 10.1038/sj.bjc.6601114 | - |
hcfmusp.relation.reference | de Visser KE, 2006, NAT REV CANCER, V6, P24, DOI 10.1038/nrc1782 | - |
hcfmusp.relation.reference | Dimitriadou V, 1997, ANTICANCER RES, V17, P1541 | - |
hcfmusp.relation.reference | DOYLE A, 1985, J EXP MED, V161, P1135, DOI 10.1084/jem.161.5.1135 | - |
hcfmusp.relation.reference | Fricke I, 2006, IMMUNOL INVEST, V35, P459, DOI 10.1080/08820130600803429 | - |
hcfmusp.relation.reference | Gong Xuanju, 2000, Zhonghua Zhongliu Zazhi, V22, P135 | - |
hcfmusp.relation.reference | Gordon SB, 2002, BRIT MED BULL, V61, P45, DOI 10.1093/bmb/61.1.45 | - |
hcfmusp.relation.reference | Green RM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006860 | - |
hcfmusp.relation.reference | Ishigami S, 2000, CANCER, V88, P577, DOI 10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V | - |
hcfmusp.relation.reference | Iwamoto M, 2003, INT J CANCER, V104, P92, DOI 10.1002/ijc.10915 | - |
hcfmusp.relation.reference | Kataki A, 2002, J LAB CLIN MED, V140, P320, DOI 10.1067/mlc.2002.128317 | - |
hcfmusp.relation.reference | Matheus RS, 2004, PATHOL RES PRACT, V200, P13, DOI 10.1016/j.prp.2003.12.007 | - |
hcfmusp.relation.reference | META M, 1995, CANCER IMMUNOL IMMUN, V40, P235, DOI 10.1007/BF01519897 | - |
hcfmusp.relation.reference | Minamoto H, 2003, HISTOPATHOLOGY, V43, P427, DOI 10.1046/j.1365-2559.2003.01704.x | - |
hcfmusp.relation.reference | Moriya K, 2010, CANCER IMMUNOL IMMUN, V59, P1083, DOI 10.1007/s00262-010-0835-z | - |
hcfmusp.relation.reference | Neves AR, 2005, CANCER IMMUNOL IMMUN, V54, P61, DOI 10.1007/s00262-004-0550-8 | - |
hcfmusp.relation.reference | O'Mahony D, 2005, J CLIN ONCOL, V23, P1 | - |
hcfmusp.relation.reference | Parra ER, 2008, HISTOL HISTOPATHOL, V23, P987 | - |
hcfmusp.relation.reference | Porta C, 2007, ANTICANCER RES, V27, P165 | - |
hcfmusp.relation.reference | Rodrigues OR, 1997, JPN J CLIN ONCOL, V27, P298, DOI 10.1093/jjco/27.5.298 | - |
hcfmusp.relation.reference | Saito DMS, 2007, HISTOPATHOLOGY, V50, P525, DOI 10.1111/j.1365-2559.2007.02623.x | - |
hcfmusp.relation.reference | Sallusto P, 1994, J EXP MED, V179, P1109 | - |
hcfmusp.relation.reference | Sandel MH, 2005, CLIN CANCER RES, V11, P2576, DOI 10.1158/1078-0432.CCR-04-1448 | - |
hcfmusp.relation.reference | Schrump D, 2005, CANC PRINCIPLES PRAC, P753 | - |
hcfmusp.relation.reference | Souza P, 2010, HUM PATHOL, V41, P239, DOI 10.1016/j.humpath.2009.07.018 | - |
hcfmusp.relation.reference | TAKAHASHI H, 1993, INT IMMUNOL, V5, P849, DOI 10.1093/intimm/5.8.849 | - |
hcfmusp.relation.reference | Takanami I, 2001, J THORAC CARDIOV SUR, V121, P1058, DOI 10.1067/2001.113026 | - |
hcfmusp.relation.reference | Tataroglu C, 2004, LUNG CANCER-J IASLC, V43, P47, DOI 10.1016/j.lungcan.2003.08.013 | - |
hcfmusp.relation.reference | Vermaelen KY, 2001, J EXP MED, V193, P51 | - |
hcfmusp.relation.reference | Villegas FR, 2002, LUNG CANCER-J IASLC, V35, P23, DOI 10.1016/S0169-5002(01)00292-6 | - |
hcfmusp.relation.reference | Weibel ER, 1990, MODELS LUNG DIS MICR, P199 | - |
hcfmusp.relation.reference | Welsh TJ, 2005, J CLIN ONCOL, V23, P8959, DOI 10.1200/JCO.2005.01.4910 | - |
hcfmusp.relation.reference | Wu J, 2003, ADV CANCER RES, V90, P127, DOI 10.1016/S0065-230X(03)90004-2 | - |
hcfmusp.relation.reference | ZHOU LJ, 1992, J IMMUNOL, V149, P735 | - |
hcfmusp.relation.reference | Zou WP, 2005, NAT REV CANCER, V5, P263, DOI 10.1038/nrc1586 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.remissive.sponsorship | FMUSP-HC | - |
hcfmusp.citation.scopus | 14 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SOUZA_Different_morphology_stage_and_treatment_affect_immune_cell_2012.PDF Restricted Access | publishedVersion (English) | 1.18 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.