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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | VIEIRA, Rodolfo de Paula | - |
dc.contributor.author | TOLEDO, Alessandra Choqueta | - |
dc.contributor.author | SILVA, Lucas Bogaz | - |
dc.contributor.author | ALMEIDA, Francine Maria | - |
dc.contributor.author | DAMACENO-RODRIGUES, Nilsa Regina | - |
dc.contributor.author | CALDINI, Elia Garcia | - |
dc.contributor.author | SANTOS, Angela Batista Gomes | - |
dc.contributor.author | RIVERO, Dolores Helena | - |
dc.contributor.author | HIZUME, Deborah Camargo | - |
dc.contributor.author | LOPES, Fernanda Degobbi Tenorio Quirino Santos | - |
dc.contributor.author | OLIVO, Clarice Rosa | - |
dc.contributor.author | CASTRO-FARIA-NETO, Hugo Caire | - |
dc.contributor.author | MARTINS, Milton Arruda | - |
dc.contributor.author | SALDIVA, Paulo Hilario Nascimento | - |
dc.contributor.author | DOLHNIKOFF, Marisa | - |
dc.date.accessioned | 2013-07-30T15:14:56Z | - |
dc.date.available | 2013-07-30T15:14:56Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.44, n.7, p.1227-1234, 2012 | - |
dc.identifier.issn | 0195-9131 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/952 | - |
dc.description.abstract | Purpose: Exposure to diesel exhaust particles (DEP) results in lung inflammation. Regular aerobic exercise improves the inflammatory status in different pulmonary diseases. However, the effects of long-term aerobic exercise on the pulmonary response to DEP have not been investigated. The present study evaluated the effect of aerobic conditioning on the pulmonary inflammatory and oxidative responses of mice exposed to DEP. Methods: BALB/c mice were subjected to aerobic exercise five times per week for 5 wk, concomitantly with exposure to DEP (3 mg.mL (1); 10 mu L per mouse). The levels of exhaled nitric oxide, reactive oxygen species, cellularity, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) were analyzed in bronchoalveolar lavage fluid, and the density of neutrophils and the volume proportion of collagen fibers were measured in the lung parenchyma. The cellular density of leukocytes expressing IL-1 beta, keratinocyte chemoattractant (KC), and TNF-alpha in lung parenchyma was evaluated with immunohistochemistry. The levels of IL-1 beta, KC, and TNF-alpha were also evaluated in the serum. Results: Aerobic exercise inhibited the DEP-induced increase in the levels of reactive oxygen species (P < 0.05); exhaled nitric oxide (P < 0.01); total (P < 0.01) and differential cells (P < 0.01); IL-6 and TNF-alpha levels in bronchoalveolar lavage fluid (P < 0.05); the level of neutrophils (P < 0.001); collagen density in the lung parenchyma (P < 0.05); the levels of IL-6, KC, and TNF-alpha in plasma (P < 0.05); and the expression of IL-1 beta, KC, and TNF-alpha by leukocytes in the lung parenchyma (P < 0.01). Conclusions: We conclude that long-term aerobic exercise presents protective effects in a mouse model of DEP-induced lung inflammation. Our results indicate a need for human studies that evaluate the pulmonary responses to aerobic exercise chronically performed in polluted areas. | - |
dc.description.sponsorship | Programa Institutos Nacionais de Ciencia e Tecnologia do Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq/MCT | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) | - |
dc.description.sponsorship | Laboratorios de Investigacao Medica, Faculdade de Medicina, Universidade de Sao Paulo [FMUSP-HC/LIMs] | - |
dc.description.sponsorship | European Respiratory Society/Marie Curie Postdoctoral Fellowship | - |
dc.language.iso | eng | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.ispartof | Medicine and Science in Sports and Exercise | - |
dc.rights | restrictedAccess | - |
dc.subject | AEROBIC TRAINING | - |
dc.subject | IMMUNOLOGY | - |
dc.subject | NITROSATIVE STRESS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject.other | diesel exhaust particles | - |
dc.subject.other | inflammatory responses | - |
dc.subject.other | lung inflammation | - |
dc.subject.other | particulate matter | - |
dc.subject.other | physical-activity | - |
dc.subject.other | epithelial-cells | - |
dc.subject.other | time-course | - |
dc.subject.other | injury | - |
dc.subject.other | dysfunction | - |
dc.subject.other | expression | - |
dc.title | Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution | - |
dc.type | article | - |
dc.rights.holder | Copyright LIPPINCOTT WILLIAMS & WILKINS | - |
dc.identifier.doi | 10.1249/MSS.0b013e31824b2877 | - |
dc.identifier.pmid | 22297803 | - |
dc.subject.wos | Sport Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | VIEIRA, Rodolfo de Paula:Univ Sao Paulo, Lab Expt Air Pollut LIM 05, Dept Pathol, Sch Med, BR-01246903 Sao Paulo, Brazil; Nove Julho Univ, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, Brazil | - |
hcfmusp.author.external | SILVA, Lucas Bogaz:Univ Sao Paulo, Lab Expt Air Pollut LIM 05, Dept Pathol, Sch Med, BR-01246903 Sao Paulo, Brazil | - |
hcfmusp.author.external | HIZUME, Deborah Camargo:Univ Sao Paulo, Lab Expt Therapeut LIM 20, Dept Clin Med, Sch Med, BR-01246903 Sao Paulo, Brazil | - |
hcfmusp.author.external | CASTRO-FARIA-NETO, Hugo Caire:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Immunopharmacol, Rio De Janeiro, Brazil | - |
hcfmusp.description.beginpage | 1227 | - |
hcfmusp.description.endpage | 1234 | - |
hcfmusp.description.issue | 7 | - |
hcfmusp.description.volume | 44 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84862752830 | - |
hcfmusp.origem.id | WOS:000305473200005 | - |
hcfmusp.publisher.city | PHILADELPHIA | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Athayde KS, 2007, J ANDROL, V28, P613, DOI 10.2164/jandrol.106.001966 | - |
hcfmusp.relation.reference | Bozza FA, 2007, CRIT CARE, V11, DOI 10.1186/cc5783 | - |
hcfmusp.relation.reference | Campbell ME, 2005, CAN J PUBLIC HEALTH, V96, P24 | - |
hcfmusp.relation.reference | Cao D, 2007, AM J PHYSIOL-LUNG C, V292, pL422, DOI 10.1152/ajplung.00204.2006 | - |
hcfmusp.relation.reference | Daigle CC, 2003, INHAL TOXICOL, V15, P539, DOI 10.1080/08958370390205065 | - |
hcfmusp.relation.reference | den Hartigh LJ, 2010, TOXICOL IN VITRO, V24, P1993, DOI 10.1016/j.tiv.2010.08.017 | - |
hcfmusp.relation.reference | Dolhnikoff M, 2009, J ALLERGY CLIN IMMUN, V123, P1090, DOI 10.1016/j.jaci.2009.02.032 | - |
hcfmusp.relation.reference | Donaldson Ken, 2005, Part Fibre Toxicol, V2, P10, DOI 10.1186/1743-8977-2-10 | - |
hcfmusp.relation.reference | Gimeno D, 2011, EUR J EPIDEMIOL, V26, P135, DOI 10.1007/s10654-010-9526-5 | - |
hcfmusp.relation.reference | Halonen JI, 2008, THORAX, V63, P635, DOI 10.1136/thx.2007.091371 | - |
hcfmusp.relation.reference | Inoue K, 2006, ARCH TOXICOL, V80, P275, DOI 10.1007/s00204-005-0040-6 | - |
hcfmusp.relation.reference | Jacobs L, 2010, ENVIRON HEALTH-GLOB, V9, DOI 10.1186/1476-069X-9-64 | - |
hcfmusp.relation.reference | Ji LL, 2008, FREE RADICAL BIO MED, V44, P142, DOI 10.1016/j.freeradbiomed.2007.02.031 | - |
hcfmusp.relation.reference | Kodavanti UP, 2011, ENVIRON HEALTH PERSP, V119, P312, DOI 10.1289/ehp.1002386 | - |
hcfmusp.relation.reference | Kokkinos P, 2010, CIRCULATION, V122, P1637, DOI 10.1161/CIRCULATIONAHA.110.948349 | - |
hcfmusp.relation.reference | Laks D, 2008, INHAL TOXICOL, V20, P1037, DOI 10.1080/08958370802112922 | - |
hcfmusp.relation.reference | Leigh R, 2004, AM J RESP CRIT CARE, V169, P860, DOI 10.1164/rccm.200305-706OC | - |
hcfmusp.relation.reference | Maier KL, 2008, INHAL TOXICOL, V20, P319, DOI 10.1080/08958370701866313 | - |
hcfmusp.relation.reference | Martin S, 2010, INHAL TOXICOL, V22, P1064, DOI 10.3109/08958378.2010.523030 | - |
hcfmusp.relation.reference | Menegali BT, 2009, PULM PHARMACOL THER, V22, P567, DOI 10.1016/j.pupt.2009.08.003 | - |
hcfmusp.relation.reference | Morales MMB, 2011, CRIT CARE, V15, DOI 10.1186/cc9401 | - |
hcfmusp.relation.reference | Mussi RK, 2008, EUR RESPIR J, V31, P645, DOI 10.1183/09031936.00015607 | - |
hcfmusp.relation.reference | Nemmar A, 2010, TOXICOL LETT, V194, P58, DOI 10.1016/j.toxlet.2010.02.001 | - |
hcfmusp.relation.reference | PAFFENBARGER RS, 1986, NEW ENGL J MED, V314, P605, DOI 10.1056/NEJM198603063141003 | - |
hcfmusp.relation.reference | Pastva A, 2004, J IMMUNOL, V172, P4520 | - |
hcfmusp.relation.reference | Patel H, 2011, TOXICOL LETT, V200, P124, DOI 10.1016/j.toxlet.2010.11.007 | - |
hcfmusp.relation.reference | Patel MM, 2010, ENVIRON HEALTH PERSP, V118, P1338, DOI 10.1289/ehp.0901499 | - |
hcfmusp.relation.reference | Provoost S, 2010, J IMMUNOL, V184, P426, DOI 10.4049/jimmunol.0902564 | - |
hcfmusp.relation.reference | Radak Z, 2008, FREE RADICAL BIO MED, V44, P153, DOI 10.1016/j.freeradbiomed.2007.01.029 | - |
hcfmusp.relation.reference | Ramos DS, 2010, MED SCI SPORT EXER, V42, P113, DOI 10.1249/MSS.0b013e3181ad1c72 | - |
hcfmusp.relation.reference | Rao KMK, 2005, ENVIRON HEALTH PERSP, V113, P612, DOI 10.1289/ehp.7696 | - |
hcfmusp.relation.reference | Sharman JE, 2005, MED J AUSTRALIA, V182, P606 | - |
hcfmusp.relation.reference | Sharman JE, 2004, QJM-INT J MED, V97, P637, DOI 10.1093/qjmed/hch104 | - |
hcfmusp.relation.reference | Strak M, 2010, OCCUP ENVIRON MED, V67, P118, DOI 10.1136/oem.2009.046847 | - |
hcfmusp.relation.reference | Takano H, 2002, AM J RESP CRIT CARE, V165, P1329, DOI 10.1164/rccm20108122 | - |
hcfmusp.relation.reference | Toledo AC, 2012, EUR RESPIR J, V39, P254, DOI 10.1183/09031936.00003411 | - |
hcfmusp.relation.reference | Vieira RP, 2008, AM J PHYSIOL-LUNG C, V295, pL670, DOI 10.1152/ajplung.00465.2007 | - |
hcfmusp.relation.reference | Vieira RP, 2009, INT J SPORTS MED, V30, P684, DOI 10.1055/s-0029-1224176 | - |
hcfmusp.relation.reference | Vieira RP, 2011, RESP PHYSIOL NEUROBI, V175, P383, DOI 10.1016/j.resp.2011.01.002 | - |
hcfmusp.relation.reference | Vieira RP, 2007, AM J RESP CRIT CARE, V176, P871, DOI 10.1164/rccm.200610-1567OC | - |
hcfmusp.relation.reference | Yoshizaki K, 2010, INHAL TOXICOL, V22, P610, DOI 10.3109/08958371003621633 | - |
hcfmusp.relation.reference | Zhao HW, 2006, ENVIRON HEALTH PERSP, V114, P1253, DOI 10.1289/ehp.9063 | - |
hcfmusp.relation.reference | Zhao HW, 2009, J TOXICOL ENV HEAL A, V72, P560, DOI 10.1080/15287390802706330 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.remissive.sponsorship | FMUSP-HC | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 63 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - LIM/20 Artigos e Materiais de Revistas Científicas - LIM/59 |
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