Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/953
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SIMOES, Davina C. M. | - |
dc.contributor.author | PSARRA, Anna-Maria G. | - |
dc.contributor.author | MAUAD, Thais | - |
dc.contributor.author | PANTOU, Ioanna | - |
dc.contributor.author | ROUSSOS, Charis | - |
dc.contributor.author | SEKERIS, Constantine E. | - |
dc.contributor.author | GRATZIOU, Christina | - |
dc.date.accessioned | 2013-07-30T15:14:56Z | - |
dc.date.available | 2013-07-30T15:14:56Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLOS ONE, v.7, n.6, article ID e39183, 12p, 2012 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/953 | - |
dc.description.abstract | Mitochondrial glucocorticoid (mtGR) and estrogen (mtER) receptors participate in the coordination of the cell's energy requirement and in the mitochondrial oxidative phosphorylation enzyme (OXPHOS) biosynthesis, affecting reactive oxygen species (ROS) generation and induction of apoptosis. Although activation of mtGR and mtER is known to trigger anti-inflammatory signals, little information exists on the presence of these receptors in lung tissue and their role in respiratory physiology and disease. Using a mouse model of allergic airway inflammation disease and applying confocal microscopy, subcellular fractionation, and Western blot analysis we showed mitochondrial localization of GR alpha and ER beta in lung tissue. Allergic airway inflammation caused reduction in mtGR alpha, mtER beta, and OXPHOS enzyme biosynthesis in lung cells mitochondria and particularly in bronchial epithelial cells mitochondria, which was accompanied by decrease in lung mitochondrial mass and induction of apoptosis. Confirmation and validation of the reduction of the mitochondrial receptors in lung epithelial cells in human asthma was achieved by analyzing autopsies from fatal asthma cases. The presence of the mitochondrial GR alpha and ER beta in lung tissue cells and especially their reduction in bronchial epithelial cells during allergic airway inflammation suggests a crucial role of these receptors in the regulation of mitochondrial function in asthma, implicating their involvement in the pathophysiology of the disease. | - |
dc.description.sponsorship | Thorax Foundation (Athens, Greece) | - |
dc.description.sponsorship | Bodosaki Foundation | - |
dc.description.sponsorship | research committee of the University of Thessaly | - |
dc.description.sponsorship | Biomedical Research Foundation of the Academy of Athens | - |
dc.description.sponsorship | CNPq Brazilian Research Council | - |
dc.language.iso | eng | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.ispartof | Plos One | - |
dc.rights | openAccess | - |
dc.subject.other | corticosteroid-induced apoptosis | - |
dc.subject.other | nuclear transcription factors | - |
dc.subject.other | airway inflammation | - |
dc.subject.other | bronchial epithelium | - |
dc.subject.other | allergic-asthma | - |
dc.subject.other | redox control | - |
dc.subject.other | rna-synthesis | - |
dc.subject.other | kappa-b | - |
dc.subject.other | er-beta | - |
dc.subject.other | alpha | - |
dc.title | Glucocorticoid and Estrogen Receptors Are Reduced in Mitochondria of Lung Epithelial Cells in Asthma | - |
dc.type | article | - |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | - |
dc.identifier.doi | 10.1371/journal.pone.0039183 | - |
dc.identifier.pmid | 22761735 | - |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SIMOES, Davina C. M.:Univ Athens, Sch Med, Dept Crit Care & Pulm Serv, GP Livanos & M Simou Labs,Evangelismos Hosp, GR-11527 Athens, Greece | - |
hcfmusp.author.external | PSARRA, Anna-Maria G.:Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece; Acad Athens, Biomed Res Fdn, Ctr Basic Res, Biochem Lab, Athens, Greece | - |
hcfmusp.author.external | PANTOU, Ioanna:Univ Athens, Sch Med, Dept Crit Care & Pulm Serv, GP Livanos & M Simou Labs,Evangelismos Hosp, GR-11527 Athens, Greece | - |
hcfmusp.author.external | ROUSSOS, Charis:Univ Athens, Sch Med, Dept Crit Care & Pulm Serv, GP Livanos & M Simou Labs,Evangelismos Hosp, GR-11527 Athens, Greece | - |
hcfmusp.author.external | SEKERIS, Constantine E.:Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, Mol Endocrinol Lab, Athens, Greece | - |
hcfmusp.author.external | GRATZIOU, Christina:Univ Athens, Sch Med, Dept Crit Care & Pulm Serv, GP Livanos & M Simou Labs,Evangelismos Hosp, GR-11527 Athens, Greece | - |
hcfmusp.description.articlenumber | e39183 | - |
hcfmusp.description.issue | 6 | - |
hcfmusp.description.volume | 7 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84863005492 | - |
hcfmusp.origem.id | WOS:000305825800022 | - |
hcfmusp.publisher.city | SAN FRANCISCO | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Adcock IM, 1996, AM J RESP CRIT CARE, V154, P771 | - |
hcfmusp.relation.reference | Alzoghaibi MA, 2007, RESPIROLOGY, V12, P439, DOI 10.1111/j.1440-1843.2007.01034.x | - |
hcfmusp.relation.reference | Bailey MT, 2009, PHYSIOL BEHAV, V98, P351, DOI 10.1016/j.physbeh.2009.06.013 | - |
hcfmusp.relation.reference | Bucchieri F, 2002, AM J RESP CELL MOL, V27, P179 | - |
hcfmusp.relation.reference | Carazo A, 2012, J CELL PHYS IN PRESS, P43 | - |
hcfmusp.relation.reference | Casas F, 1999, MOL CELL BIOL, V19, P7913 | - |
hcfmusp.relation.reference | Catley MC, 2008, J PHARMACOL EXP THER, V326, P83, DOI 10.1124/jpet.108.136275 | - |
hcfmusp.relation.reference | Chen JQ, 2007, BBA-MOL CELL RES, V1773, P1732, DOI 10.1016/j.bbamcr.2007.05.008 | - |
hcfmusp.relation.reference | Chen JQ, 2009, BBA-MOL CELL RES, V1793, P1540, DOI 10.1016/j.bbamcr.2009.06.001 | - |
hcfmusp.relation.reference | Chen JQ, 2004, J CELL BIOCHEM, V93, P358, DOI 10.1002/jcb.20178 | - |
hcfmusp.relation.reference | de Carvalho-Pinto RM, 2012, RESP MED, V106, P47, DOI 10.1016/j.rmed.2011.08.013 | - |
hcfmusp.relation.reference | DEMONACOS C, 1995, J STEROID BIOCHEM, V55, P43, DOI 10.1016/0960-0760(95)00159-W | - |
hcfmusp.relation.reference | Diaz-Sanchez D, 1999, CLIN IMMUNOL, V90, P313, DOI 10.1006/clim.1998.4676 | - |
hcfmusp.relation.reference | White SR, 2002, CHEST, V122, p278S, DOI 10.1378/chest.122.6_suppl.278S | - |
hcfmusp.relation.reference | Dorscheid DR, 2003, J ALLERGY CLIN IMMUN, V111, P360, DOI 10.1067/mai.2003.117 | - |
hcfmusp.relation.reference | Dorscheid DR, 2001, AM J RESP CRIT CARE, V164, P1939 | - |
hcfmusp.relation.reference | Du J, 2009, P NATL ACAD SCI USA, V106, P3543, DOI 10.1073/pnas.0812671106 | - |
hcfmusp.relation.reference | Enriquez JA, 1999, MOL CELL BIOL, V19, P657 | - |
hcfmusp.relation.reference | Evans RM, 2005, MOL ENDOCRINOL, V19, P1429, DOI 10.1210/me.2005-0046 | - |
hcfmusp.relation.reference | Goldenthal MJ, 2004, MOL CELL BIOCHEM, V262, P1, DOI 10.1023/B:MCBI.0000038228.85494.3b | - |
hcfmusp.relation.reference | Green FHY, 2010, THORAX, V65, P32, DOI 10.1136/thx.2008.111435 | - |
hcfmusp.relation.reference | HANTOS Z, 1992, J APPL PHYSIOL, V72, P168 | - |
hcfmusp.relation.reference | Hsieh YC, 2006, J MOL CELL CARDIOL, V41, P511, DOI 10.1016/j.yjmcc.2006.06.001 | - |
hcfmusp.relation.reference | HULSMANN AR, 1994, AM J RESP CRIT CARE, V149, P519 | - |
hcfmusp.relation.reference | Ivanova MM, 2009, MOL CELL ENDOCRINOL, V305, P12, DOI 10.1016/j.mce.2009.01.021 | - |
hcfmusp.relation.reference | Janssen-Heininger Yvonne M W, 2009, Proc Am Thorac Soc, V6, P249, DOI 10.1513/pats.200806-054RM | - |
hcfmusp.relation.reference | Kannan MS, 2003, AM J PHYSIOL-LUNG C, V285, pL29, DOI 10.1152/ajplung.00085.2003 | - |
hcfmusp.relation.reference | Korn SH, 1997, AM J RESP CRIT CARE, V155, P1117 | - |
hcfmusp.relation.reference | Kroemer G, 2000, NAT MED, V6, P513, DOI 10.1038/74994 | - |
hcfmusp.relation.reference | Lu NZ, 2004, ANN NY ACAD SCI, V1024, P102, DOI 10.1196/annals.1321.008 | - |
hcfmusp.relation.reference | Mabalirajan U, 2008, J IMMUNOL, V181, P3540 | - |
hcfmusp.relation.reference | MANDERS EMM, 1993, J MICROSC-OXFORD, V169, P375 | - |
hcfmusp.relation.reference | Modig L, 2009, EUR RESPIR J, V33, P1261, DOI 10.1183/09031936.00101108 | - |
hcfmusp.relation.reference | Montoya J, 2006, BBA-BIOENERGETICS, V1757, P1179, DOI 10.1016/j.bbabio.2006.03.023 | - |
hcfmusp.relation.reference | Otto C, 1997, J BIOL CHEM, V272, P26665, DOI 10.1074/jbc.272.42.26665 | - |
hcfmusp.relation.reference | Psarra AMG, 2009, BBA-BIOENERGETICS, V1787, P431, DOI 10.1016/j.bbabio.2008.11.011 | - |
hcfmusp.relation.reference | Psarra AMG, 2011, BBA-MOL CELL RES, V1813, P1814, DOI 10.1016/j.bbamcr.2011.05.014 | - |
hcfmusp.relation.reference | Psarra AMG, 2009, BIOCHEM J, V422, P521, DOI 10.1042/BJ20090107 | - |
hcfmusp.relation.reference | Psarra AMG, 2005, INT J BIOCHEM CELL B, V37, P2544, DOI 10.1016/j.biocel.2005.06.015 | - |
hcfmusp.relation.reference | Psarra AMG, 2008, BBA-MOL CELL RES, V1783, P1, DOI 10.1016/j.bbamcr.2007.10.021 | - |
hcfmusp.relation.reference | Riedl MA, 2008, CURR OPIN ALLERGY CL, V8, P49, DOI 10.1097/ACI.0b013e3282f3d913 | - |
hcfmusp.relation.reference | Saffar AS, 2007, J IMMUNOL, V178, P2535 | - |
hcfmusp.relation.reference | Sekeris C E, 1990, In Vivo, V4, P317 | - |
hcfmusp.relation.reference | Simoes DCM, 2008, AM J RESP CRIT CARE, V177, P1314, DOI 10.1164/rccm.200708-1141OC | - |
hcfmusp.relation.reference | Simoes DCM, 2009, AM J RESP CRIT CARE, V179, P894, DOI 10.1164/rccm.200807-1081OC | - |
hcfmusp.relation.reference | Sionov RV, 2006, J EXP MED, V203, P189, DOI 10.1084/jem.20050433 | - |
hcfmusp.relation.reference | Solakidi S, 2005, HUM REPROD, V20, P3481, DOI 10.1093/humrep/dei267 | - |
hcfmusp.relation.reference | Srere PA., 1969, METHOD ENZYMOL, V13, P3 | - |
hcfmusp.relation.reference | Trian T, 2007, J EXP MED, V204, P3173, DOI 10.1084/jem.20070956 | - |
hcfmusp.relation.reference | Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478 | - |
hcfmusp.relation.reference | Ueda S, 2002, ANTIOXID REDOX SIGN, V4, P405, DOI 10.1089/15230860260196209 | - |
hcfmusp.relation.reference | Vignola AM, 1998, AM J RESP CRIT CARE, V157, P403 | - |
hcfmusp.relation.reference | Walsh GM, 2003, J ENDOCRINOL, V178, P37, DOI 10.1677/joe.0.1780037 | - |
hcfmusp.relation.reference | Xanthou G, 2007, NAT MED, V13, P570, DOI 10.1038/nm1580 | - |
hcfmusp.relation.reference | Yang SH, 2009, J BIOL CHEM, V284, P9540, DOI 10.1074/jbc.M808246200 | - |
hcfmusp.relation.reference | Zinchuk V, 2007, ACTA HISTOCHEM CYTOC, V40, P101, DOI 10.1267/ahc.07002 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 34 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/05 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_MAUAD_Glucocorticoid_and_Estrogen_Receptors_Are_Reduced_in_Mitochondria_2012.PDF | publishedVersion (English) | 887.45 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.