Use este identificador para citar ou linkar para este item: https://observatorio.fm.usp.br/handle/OPI/955
Título: Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model
Autor(es): CRUZ, Fernanda F.ANTUNES, Mariana A.ABREU, Soraia C.FUJISAKI, Livia C.SILVA, Johnatas D.XISTO, Debora G.MARON-GUTIERREZ, TatianaORNELLAS, Debora S.SA, Vanessa K.ROCHA, Nazareth N.CAPELOZZI, Vera L.MORALES, Marcelo M.ROCCO, Patricia R. M.
Parte de: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.182, n.1, p.26-36, 2012
Resumo: We hypothesized that bone marrow-derived mononuclear cell (BMDMC) therapy protects the lung and consequently the heart in experimental elastase-induced emphysema. Twenty-four female C57BL/6 mice were intratracheally instilled with saline (C group) or porcine pancreatic elastase (E group) once a week during 4 weeks. C and E groups were randomized into subgroups receiving saline (SAL) or male BMDMCs (2 x 10(6), CELL) intravenously 3 h after the first saline or elastase instillation. Compared to E-SAL group, E-CELL mice showed, at 5 weeks: lower mean linear intercept, neutrophil infiltration, elastolysis, collagen fiber deposition in alveolar septa and pulmonary vessel wall, lung cell apoptosis, right ventricle wall thickness and area, higher endothelial growth factor and insulin-like growth factor mRNA expressions in lung tissue, and reduced platelet-derived growth factor, transforming growth factor-beta, and caspase-3 expressions. In conclusion, BMDMC therapy was effective at modulating the inflammatory and remodeling processes in the present model of elastase-induced emphysema.
Aparece nas coleções:

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT


Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
art_SA_Protective_effects_of_bone_marrow_mononuclear_cell_therapy_2012.PDF
  Restricted Access
publishedVersion (English)2.77 MBAdobe PDFVisualizar/Abrir    Solicitar uma cópia

Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.