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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCRUZ, Fernanda F.-
dc.contributor.authorANTUNES, Mariana A.-
dc.contributor.authorABREU, Soraia C.-
dc.contributor.authorFUJISAKI, Livia C.-
dc.contributor.authorSILVA, Johnatas D.-
dc.contributor.authorXISTO, Debora G.-
dc.contributor.authorMARON-GUTIERREZ, Tatiana-
dc.contributor.authorORNELLAS, Debora S.-
dc.contributor.authorSA, Vanessa K.-
dc.contributor.authorROCHA, Nazareth N.-
dc.contributor.authorCAPELOZZI, Vera L.-
dc.contributor.authorMORALES, Marcelo M.-
dc.contributor.authorROCCO, Patricia R. M.-
dc.date.accessioned2013-07-30T15:14:56Z-
dc.date.available2013-07-30T15:14:56Z-
dc.date.issued2012-
dc.identifier.citationRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.182, n.1, p.26-36, 2012-
dc.identifier.issn1569-9048-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/955-
dc.description.abstractWe hypothesized that bone marrow-derived mononuclear cell (BMDMC) therapy protects the lung and consequently the heart in experimental elastase-induced emphysema. Twenty-four female C57BL/6 mice were intratracheally instilled with saline (C group) or porcine pancreatic elastase (E group) once a week during 4 weeks. C and E groups were randomized into subgroups receiving saline (SAL) or male BMDMCs (2 x 10(6), CELL) intravenously 3 h after the first saline or elastase instillation. Compared to E-SAL group, E-CELL mice showed, at 5 weeks: lower mean linear intercept, neutrophil infiltration, elastolysis, collagen fiber deposition in alveolar septa and pulmonary vessel wall, lung cell apoptosis, right ventricle wall thickness and area, higher endothelial growth factor and insulin-like growth factor mRNA expressions in lung tissue, and reduced platelet-derived growth factor, transforming growth factor-beta, and caspase-3 expressions. In conclusion, BMDMC therapy was effective at modulating the inflammatory and remodeling processes in the present model of elastase-induced emphysema.-
dc.description.sponsorshipCentres of Excellence Program (PRONEX-CNPq/FAPERJ)-
dc.description.sponsorshipBrazilian Council for Scientific and Technological Development (MCT/CNPq)-
dc.description.sponsorshipCarlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ)-
dc.description.sponsorshipSao Paulo State Research Support Foundation (FAPESP)-
dc.description.sponsorshipNational Institute of Science and Technology of Drugs and Medicine (INCT-INOFAR)-
dc.description.sponsorshipCoordination for the Improvement of Higher Level Personnel (CAPES)-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE BV-
dc.relation.ispartofRespiratory Physiology & Neurobiology-
dc.rightsrestrictedAccess-
dc.subjectElastase-
dc.subjectEmphysema-
dc.subjectRemodeling-
dc.subjectStem cells-
dc.subjectCardiovascular function-
dc.subject.otherobstructive pulmonary-disease-
dc.subject.othermesenchymal stem-cells-
dc.subject.otherendothelial growth-factor-
dc.subject.otherinjury-
dc.subject.otherfibrosis-
dc.subject.otherrepair-
dc.subject.othertransplantation-
dc.subject.otherinflammation-
dc.subject.othercopd-
dc.subject.othermice-
dc.titleProtective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.identifier.doi10.1016/j.resp.2012.01.002-
dc.identifier.pmid22266352-
dc.subject.wosPhysiology-
dc.subject.wosRespiratory System-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalXISTO, Debora G.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalMARON-GUTIERREZ, Tatiana:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalORNELLAS, Debora S.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalROCHA, Nazareth N.:Univ Fed Fluminense, Dept Physiol, Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalMORALES, Marcelo M.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalROCCO, Patricia R. M.:Univ Fed Rio de Janeiro, Lab Pulm Invest, Carlos Chagas Filho Biophys Inst, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.description.beginpage26-
hcfmusp.description.endpage36-
hcfmusp.description.issue1-
hcfmusp.description.volume182-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84861670869-
hcfmusp.origem.idWOS:000305722700004-
hcfmusp.publisher.cityAMSTERDAM-
hcfmusp.publisher.countryNETHERLANDS-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPERJ-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipINCTs-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPERJ-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipINCTs-
hcfmusp.citation.scopus42-
hcfmusp.scopus.lastupdate2022-06-23-
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