Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCRUZ, Fernanda F.-
dc.contributor.authorANTUNES, Mariana A.-
dc.contributor.authorABREU, Soraia C.-
dc.contributor.authorFUJISAKI, Livia C.-
dc.contributor.authorSILVA, Johnatas D.-
dc.contributor.authorXISTO, Debora G.-
dc.contributor.authorMARON-GUTIERREZ, Tatiana-
dc.contributor.authorORNELLAS, Debora S.-
dc.contributor.authorSA, Vanessa K.-
dc.contributor.authorROCHA, Nazareth N.-
dc.contributor.authorCAPELOZZI, Vera L.-
dc.contributor.authorMORALES, Marcelo M.-
dc.contributor.authorROCCO, Patricia R. M.-
dc.identifier.citationRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.182, n.1, p.26-36, 2012-
dc.description.abstractWe hypothesized that bone marrow-derived mononuclear cell (BMDMC) therapy protects the lung and consequently the heart in experimental elastase-induced emphysema. Twenty-four female C57BL/6 mice were intratracheally instilled with saline (C group) or porcine pancreatic elastase (E group) once a week during 4 weeks. C and E groups were randomized into subgroups receiving saline (SAL) or male BMDMCs (2 x 10(6), CELL) intravenously 3 h after the first saline or elastase instillation. Compared to E-SAL group, E-CELL mice showed, at 5 weeks: lower mean linear intercept, neutrophil infiltration, elastolysis, collagen fiber deposition in alveolar septa and pulmonary vessel wall, lung cell apoptosis, right ventricle wall thickness and area, higher endothelial growth factor and insulin-like growth factor mRNA expressions in lung tissue, and reduced platelet-derived growth factor, transforming growth factor-beta, and caspase-3 expressions. In conclusion, BMDMC therapy was effective at modulating the inflammatory and remodeling processes in the present model of elastase-induced emphysema.-
dc.description.sponsorshipCentres of Excellence Program (PRONEX-CNPq/FAPERJ)-
dc.description.sponsorshipBrazilian Council for Scientific and Technological Development (MCT/CNPq)-
dc.description.sponsorshipCarlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ)-
dc.description.sponsorshipSao Paulo State Research Support Foundation (FAPESP)-
dc.description.sponsorshipNational Institute of Science and Technology of Drugs and Medicine (INCT-INOFAR)-
dc.description.sponsorshipCoordination for the Improvement of Higher Level Personnel (CAPES)-
dc.relation.ispartofRespiratory Physiology & Neurobiology-
dc.subjectStem cells-
dc.subjectCardiovascular function-
dc.subject.otherobstructive pulmonary-disease-
dc.subject.othermesenchymal stem-cells-
dc.subject.otherendothelial growth-factor-
dc.titleProtective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model-
dc.rights.holderCopyright ELSEVIER SCIENCE BV-
dc.subject.wosRespiratory System-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Debora G.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-, Tatiana:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-, Debora S.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-, Nazareth N.:Univ Fed Fluminense, Dept Physiol, Rio De Janeiro, RJ, Brazil-, Marcelo M.:Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, RJ, Brazil-, Patricia R. M.:Univ Fed Rio de Janeiro, Lab Pulm Invest, Carlos Chagas Filho Biophys Inst, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.relation.referenceAbdollahi A, 2005, J EXP MED, V201, P925, DOI 10.1084/jem.20041393-
hcfmusp.relation.referenceAbreu SC, 2011, RESP PHYSIOL NEUROBI, V175, P153, DOI 10.1016/j.resp.2010.10.006-
hcfmusp.relation.referenceAbreu SC, 2011, INTENS CARE MED, V37, P1421, DOI 10.1007/s00134-011-2268-3-
hcfmusp.relation.referenceAgusti AGN, 2003, EUR RESPIR J, V21, P347, DOI 10.1183/09031936.03.00405703-
hcfmusp.relation.referenceAntunes M.A., 2011, AN ACAD BRAS CIENC-
hcfmusp.relation.referenceAraujo IM, 2010, CRIT CARE MED, V38, P1733, DOI 10.1097/CCM.0b013e3181e796d2-
hcfmusp.relation.referenceArunachalam G., 2010, J INFLAMM-LOND, V22, P7-
hcfmusp.relation.referenceBarbera JA, 2003, EUR RESPIR J, V21, P892, DOI 10.1183/09031936.03.00115402-
hcfmusp.relation.referenceBarnes PJ, 2005, EUR RESPIR J, V25, P1084, DOI 10.1183/09031936.05.00139104-
hcfmusp.relation.referenceBarr RG, 2010, NEW ENGL J MED, V362, P217, DOI 10.1056/NEJMoa0808836-
hcfmusp.relation.referenceBonsignore Maria R, 2006, Proc Am Thorac Soc, V3, P537, DOI 10.1513/pats.200603-090MS-
hcfmusp.relation.referenceBrussel GG, 2011, LANCET, V378, P1015, DOI 10.1016/S0140-6736(11)60988-4-
hcfmusp.relation.referenceChurg A., 2011, EUR RESP J-
hcfmusp.relation.referenceCottin V, 2005, EUR RESPIR J, V26, P586, DOI 10.1183/09031936.05.00021005-
hcfmusp.relation.referenceDoorn J., 2011, TISSUE ENG B-
hcfmusp.relation.referenceDUNNILL M. S., 1964, THORAX, V19, P443, DOI 10.1136/thx.19.5.443-
hcfmusp.relation.referenceFabbri LM, 2006, AM J RESP CRIT CARE, V173, P1056, DOI 10.1164/rccm.2603005-
hcfmusp.relation.referenceFabbri LM, 2008, EUR RESPIR J, V31, P204, DOI 10.1183/09031936.00114307-
hcfmusp.relation.referenceFehrenbach H, 1999, ANAT REC, V254, P61, DOI 10.1002/(SICI)1097-0185(19990101)254:1<61::AID-AR8>3.0.CO;2-D-
hcfmusp.relation.referenceFullmer H M, 1974, J Oral Pathol, V3, P291, DOI 10.1111/j.1600-0714.1974.tb01724.x-
hcfmusp.relation.referenceGupta N, 2007, J IMMUNOL, V179, P1855-
hcfmusp.relation.referenceHamakawa H., 2010, AM J RESP CELL MOL B-
hcfmusp.relation.referenceHattori K, 2001, J EXP MED, V193, P1005, DOI 10.1084/jem.193.9.1005-
hcfmusp.relation.referenceHoyle GW, 1999, AM J PATHOL, V154, P1763, DOI 10.1016/S0002-9440(10)65432-6-
hcfmusp.relation.referenceHuertas Alice, 2011, Ther Adv Respir Dis, V5, P217, DOI 10.1177/1753465811400490-
hcfmusp.relation.referenceHuertas A, 2010, RESP PHYSIOL NEUROBI, V170, P23, DOI 10.1016/j.resp.2009.10.003-
hcfmusp.relation.referenceHuh J.W., 2011, AM J PHYSIOL-LUNG C, V301, P255-
hcfmusp.relation.referenceJorgensen K, 2007, CHEST, V131, P1050, DOI 10.1378/chest.06-2245-
hcfmusp.relation.referenceKatsha AM, 2011, MOL THER, V19, P196, DOI 10.1038/mt.2010.192-
hcfmusp.relation.referenceKrause Diane S, 2008, Proc Am Thorac Soc, V5, P323, DOI 10.1513/pats.200712-169DR-
hcfmusp.relation.referenceLang RM, 2006, EUR J ECHOCARDIOGR, V7, P79, DOI 10.1016/j.euje.2005.12.014-
hcfmusp.relation.referenceLIEBOW AA, 1959, AM REV RESPIR DIS, V80, P67-
hcfmusp.relation.referenceLolmede K, 2009, J LEUKOCYTE BIOL, V85, P779, DOI 10.1189/jlb.0908579-
hcfmusp.relation.referenceLuthje L, 2009, RESP RES, V10, DOI 10.1186/1465-9921-10-7-
hcfmusp.relation.referenceMannino David M, 2007, Proc Am Thorac Soc, V4, P502, DOI 10.1513/pats.200701-001FM-
hcfmusp.relation.referenceMaron-Gutierrez T, 2011, EUR RESPIR J, V37, P1217, DOI 10.1183/09031936.00205009-
hcfmusp.relation.referenceMorty Rory E, 2009, Proc Am Thorac Soc, V6, P607, DOI 10.1513/pats.200908-087RM-
hcfmusp.relation.referenceOliveira GP, 2009, CRIT CARE, V13, DOI 10.1186/cc7888-
hcfmusp.relation.referenceOrtiz LA, 2007, P NATL ACAD SCI USA, V104, P11002, DOI 10.1073/pnas.0704421104-
hcfmusp.relation.referenceOskowitz A, 2011, STEM CELL RES, V6, P215, DOI 10.1016/j.scr.2011.01.004-
hcfmusp.relation.referenceProta LFM, 2010, CELL TRANSPLANT, V19, P965, DOI 10.3727/096368910X506845-
hcfmusp.relation.referenceRabe KF, 2011, LANCET, V378, P1038, DOI 10.1016/S0140-6736(11)61295-6-
hcfmusp.relation.referenceRasmusson I, 2006, EXP CELL RES, V312, P2169, DOI 10.1016/j.yexcr.2006.03.019-
hcfmusp.relation.referenceRojas M, 2005, AM J RESP CELL MOL, V33, P145, DOI 10.1165/rcmb.2004-0330OC-
hcfmusp.relation.referenceSadat S, 2007, BIOCHEM BIOPH RES CO, V363, P674, DOI 10.1016/j.bbrc.2007.09.058-
hcfmusp.relation.referenceSchweitzer KS, 2011, AM J RESP CRIT CARE, V183, P215, DOI 10.1164/rccm.201001-0126OC-
hcfmusp.relation.referenceShigemura N, 2006, AM J TRANSPLANT, V6, P2592, DOI 10.1111/j.1600-6143.2006.01522.x-
hcfmusp.relation.referenceSNIDER GL, 1985, CHEST, V87, pS35, DOI 10.1378/chest.87.1_Supplement.35S-
hcfmusp.relation.referenceSutherland ER, 2004, NEW ENGL J MED, V350, P2689, DOI 10.1056/NEJMra030415-
hcfmusp.relation.referenceTaraseviciene-Stewart L, 2008, J CLIN INVEST, V118, P394, DOI [10.1172/JCI31811, 10.1172/JC131811]-
hcfmusp.relation.referenceWeibel ER, 1990, MODELS LUNG DIS MICR, P199-
hcfmusp.relation.referenceXu JG, 2007, AM J PHYSIOL-LUNG C, V293, pL131, DOI 10.1152/ajplung.00431.2006-
hcfmusp.relation.referenceYamada M, 2004, J IMMUNOL, V172, P1266-
hcfmusp.relation.referenceYamashita N, 2005, CELL IMMUNOL, V235, P85, DOI 10.1016/j.cellimm.2005.07.006-
hcfmusp.relation.referenceYoshida H, 2009, ANN THORAC SURG, V88, P418, DOI 10.1016/j.athoracsur.2009.04.105-
hcfmusp.relation.referenceZhen GH, 2010, CYTOTHERAPY, V12, P605, DOI 10.3109/14653241003745888-
hcfmusp.relation.referenceZhen GH, 2008, FRONT BIOSCI, V13, P3415-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)2.77 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.