Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/962
Title: Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung
Authors: SA, Vanessa Karen deOLIVIERI, EloisaPARRA, Edwin RogerAB'SABER, Alexandre MuxfeldtTAKAGAKI, TeresaSOARES, Fernando AugustoCARRARO, DirceCARVALHO, LinaCAPELOZZI, Vera Luiza
Citation: HUMAN PATHOLOGY, v.43, n.5, p.675-683, 2012
Abstract: Heterogeneity of hyaluronidase (HYAL) expression has been identified in tumors and shows promise as an indicator of disease progression. The expression profile of alternatively spliced forms of HYAL was evaluated in tumors and normal lung tissue from 69 resected tumors of patients with adenocarcinomas and squamous cell carcinomas. HYAL1-wild-type (wt) and variants 1 to 5, HYAL2-wt, and HYAL3-wt, and variants 1 to 3 were identified by polymerase chain reaction and direct sequencing. Different proportions of the 3 HYAL-wt and variants were expressed in tumor and normal lung tissues. HYAL1-wt was associated with a poorer prognosis and HYAL3-vl with a better prognosis. HYAL splice variants are associated with histology and outcome, suggesting that strategies aimed at modulating their levels may be effective for lung cancer treatment.
Appears in Collections:Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC

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