Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/9824
Title: | What is the influence of hormone therapy on homocysteine and crp levels in postmenopausal women? |
Authors: | LAKRYC, Eli Marcelo; MACHADO, Rogerio Bonassi; SOARES JR., Jose Maria; BARACAT, Edmund Chada |
Citation: | CLINICS, v.70, n.2, p.107-113, 2015 |
Abstract: | OBJECTIVE: To evaluate the influence of estrogen therapy and estrogen-progestin therapy on homocysteine and C-reactive protein levels in postmenopausal women. METHODS: In total, 99 postmenopausal women were included in this double-blind, randomized clinical trial and divided into three groups: Group A used estrogen therapy alone (2.0 mg of 17 beta-estradiol), Group B received estrogen-progestin therapy (2.0 mg of 17 beta-estradiol +1.0 mg of norethisterone acetate) and Group C received a placebo (control). The length of treatment was six months. Serum measurements of homocysteine and C-reactive protein were carried out prior to the onset of treatment and following six months of therapy. RESULTS: After six months of treatment, there was a 20.7% reduction in homocysteine levels and a 100.5% increase in C-reactive protein levels in the group of women who used estrogen therapy. With respect to the estrogen-progestin group, there was a 12.2% decrease in homocysteine levels and a 93.5% increase in C-reactive protein levels. CONCLUSION: Our data suggested that hormone therapy (unopposed estrogen or estrogen associated with progestin) may have a positive influence on decreasing cardiovascular risk due to a significant reduction in homocysteine levels. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_LAKRYC_What_is_the_influence_of_hormone_therapy_on_2015.PDF | publishedVersion (English) | 312.01 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.