Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPGIGLIOBIANCO, GiuliaREGUEROS, Sabiniano RomanOSMAN, Nadir I.BISSOLI, JulioBULLOCK, Anthony J.CHAPPLE, Chris R.MACNEIL, Sheila2015-08-142015-08-142015BIOMED RESEARCH INTERNATIONAL, article ID 968087, 20p, 20152314-6133https://observatorio.fm.usp.br/handle/OPI/9908Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.engopenAccesssmall-intestinal submucosastress urinary-incontinencefree vaginal tapebody-wall repairtime-dependent variationscadaveric fascia lataquality-of-lifevivo rat modelhost responsein-vivoarticleCopyright HINDAWI PUBLISHING CORPORATION10.1155/2015/968087Biotechnology & Applied MicrobiologyMedicine, Research & Experimental2314-6141