Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPDANILOVIC, A.LUCON, A. M.SROUGI, M.SHIMIZU, M. H. M.IANHEZ, L. E.NAHAS, W. C.SEGURO, A. C.2017-11-272017-11-272011TRANSPLANTATION PROCEEDINGS, v.43, n.5, p.1443-1449, 20110041-1345https://observatorio.fm.usp.br/handle/OPI/22496We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.engrestrictedAccessischemia-reperfusion injuryacetyl-cysteinekidney-transplantationinduced nephrotoxicityserum creatininefailurepredictiondecreasestressmodelarticleCopyright ELSEVIER SCIENCE INC10.1016/j.transproceed.2011.02.020ImmunologySurgeryTransplantation