Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPCURY-MARTINS, J.SANCHES, J. A.2023-12-042023-12-042023Cury-Martins, J.; Sanches, J. A.. Dermatological Manifestations. In: . Amyloidosis and Fabry Disease: a Clinical Guide: SPRINGER INTERNATIONAL PUBLISHING, 2023. p.97-105.978-303117759-0; 978-303117758-3https://observatorio.fm.usp.br/handle/OPI/57184Cutaneous involvement by amyloidosis is characterized by extracellular deposition of amyloid protein within the skin and appendages and can occur as a skin-limited disorder (localized cutaneous amyloidosis—LCA) or as a manifestation of systemic amyloidosis (SA). LCA can be divided into primary LCA—macular, lichen and nodular amyloidosis; or secondary LCA. The main subtypes of SA with cutaneous involvement include immunoglobulin light chain (AL) amyloidosis, secondary (AA) amyloidosis, dialysis-related amyloidosis, and heredofamilial amyloidosis. Skin involvement is present, for example, in approximately 40% of patients with AL amyloidosis, and might provide an early clue to the existence of an underlying plasma-cell dyscrasia. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.engrestrictedAccessLichen amyloidosisLocalized cutaneous amyloidosisMacular amyloidosisNodular amyloidosisSkinSystemic amyloidosis with cutaneous involvementbookPartCopyright SPRINGER INTERNATIONAL PUBLISHING10.1007/978-3-031-17759-0_10