Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPSALES, Thais Lorenna SouzaSOUZA-SILVA, Maira Viana RegoDELFINO-PEREIRA, PoliannaNEVES, Joao Victor BaroniSACIOTO, Manuela FurtadoASSIS, Vivian Costa Morais deDUANI, HelenaOLIVEIRA, Neimy Ramos deSAMPAIO, Natalia da Cunha SeverinoRAMOS, Lucas Emanuel FerreiraSCHWARZBOLD, Alexandre VargasJORGE, Alzira de OliveiraSCOTTON, Ana Luiza Bahia AlvesCASTRO, Bruno Mateus deSILVA, Carla Thais Candida Alves daRAMOS, Carolina MarquesANSCHAU, FernandoBOTONI, Fernando AntonioGRIZENDE, Genna Maira SantosNASCIMENTO, Guilherme FagundesRUSCHEL, Karen BrasilMENEZES, Luanna Silva MonteiroCASTRO, Luis Cesar deNASI, Luiz AntonioCARNEIRO, MarceloGODOY, Mariana Frizzo deNOGUEIRA, Matheus Carvalho AlvesJR, Milton Henriques GuimaraesZIEGELMANN, Patricia KlarmannALMEIDA, Rafaela Charao deFRANCISCO, Saionara CristinaNETO, Sidney Teodoro SilveiraARAUJO, Silvia FerreiraAVELINO-SILVA, Thiago JunqueiraALIBERTI, Marlon Juliano RomeroPIRES, Magda CarvalhoSILVA, Eduardo Sergio daMARCOLINO, Milena Soriano2023-10-302023-10-302023CLINICS, v.78, article ID 100223, 8p, 20231807-5932https://observatorio.fm.usp.br/handle/OPI/56319Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.engopenAccessCOVID-19HIVIntensive care unitMechanical ventilationMortalitycoronavirus disease 2019risk-factorsinfectionarticleCopyright ELSEVIER ESPANA10.1016/j.clinsp.2023.100223Medicine, General & Internal1980-5322