Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPDIAS, Carlos JoseCOSTA, Herikson AraujoDIAS-FILHO, Carlos Alberto AlvesFERREIRA, Andressa CoelhoRODRIGUES, BrunoIRIGOYEN, Maria ClaudiaBORGES, Antonio Carlos RomaoMARTINS, Vicenilma de AndadreVIDAL, Flavia Castello BrancoRIBEIRO, Rachel MeloSALGADO FILHO, NatalinoMOSTARDA, Cristiano T.2023-08-162023-08-162022EUROPEAN JOURNAL OF PHARMACOLOGY, v.917, article ID 174717, 7p, 20220014-2999https://observatorio.fm.usp.br/handle/OPI/55040Aim: To analyze the effect of the use of carvacrol in the cardiovascular system of spontaneously hypertensive rats (SHR). Methods: Methods: Twenty animals were allocated in four groups, one group control Wistar receiving only sorbitol, used as vehicle of administration of the carvacrol (Wistar-Vehicle), one control group SHR, also receive only sorbitol (SHR-Vehicle), a third, treated with losartan (SHR-Losartan/50 mg/kg), and the fourth, treated with carvacrol (SHR - Carvacrol/20 mg/kg). Sorbitol, losartan and carvacrol were administered by oral gavage daily for 30-day. Hemodynamic variables, vascular reactivity, biochemical parameters, and expression of Mas and AT1 receptors in kidney tissues were analyzed. Results: SHR- Carvacrol group showed a maximal effect of inhibition of 56% in the curve of norepinephrine. The Emax of the curves with Ca2+ were smaller in the groups SHR-losartan (40.17%) and SHR-carvacrol (35.71%) when compared to the SHR-Vehicle. The carvacrol increased the expression of the MAS receptors in kidney tissue. Conclusion: Thirty days of treatment with carvacrol showed an antihypertensive effect associated with less peripheral vascular resistance. Also, treatment with carvacrol increased the expression of MAS receptors in kidney tissue.engrestrictedAccessCarvacrolCardiovascularHypertensionessential oilssmooth-muscleangiotensin-(1-7)mechanismschannelsthymolsystemarticleCopyright ELSEVIER10.1016/j.ejphar.2021.174717Pharmacology & Pharmacy1879-0712