Mortality risk prediction in high-risk patients undergoing coronary artery bypass grafting: Are traditional risk scores accurate?

Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPGONCHAROV, MaximMEJIA, Omar Asdrubal VilcaARTHUR, Camila Perez de SouzaORLANDI, Bianca Maria MagliaSOUSA, AlexandreOLIVEIRA, Marco Antonio PracaATIK, Fernando AntibasSEGALOTE, Rodrigo CoelhoTIVERON, Marcos GradimSILVA, Pedro Gabriel Melo de Barros eNAKAZONE, Marcelo ArrudaLISBOA, Luiz Augusto FerreiraDALLAN, Luis Alberto OliveiraZHENG, ZheHU, ShengshouJATENE, Fabio Biscegli2021-10-202021-10-202021PLOS ONE, v.16, n.8, article ID e0255662, 13p, 20211932-6203https://observatorio.fm.usp.br/handle/OPI/42099Background The performance of traditional scores is significantly limited to predict mortality in high-risk cardiac surgery. The aim of this study was to compare the performance of STS, ESII and HiriSCORE models in predicting mortality in high-risk patients undergoing CABG. Methods Cross-sectional analysis in the international prospective database of high-risk patients: HiriSCORE project. We evaluated 248 patients with STS or ESII (5-10%) undergoing CABG in 8 hospitals in Brazil and China. The main outcome was mortality, defined as all deaths occurred during the hospitalization in which the operation was performed, even after 30 days. Five variables were selected as predictors of mortality in this cohort of patients. The model's performance was evaluated through the calibration-in-the-large and the receiver operating curve (ROC) tests. Results The mean age was 69.90 +/- 9.45, with 52.02% being female, 25% of the patients were on New York Heart Association (NYHA) class IV and 49.6% had Canadian Cardiovascular Society (CCS) class 4 angina, and 85.5% had urgency or emergency status. The mortality observed in the sample was 13.31%. The HiriSCORE model showed better calibration (15.0%) compared to ESII (6.6%) and the STS model (2.0%). In the ROC curve, the HiriSCORE model showed better accuracy (ROC = 0.74) than the traditional models STS (ROC = 0.67) and ESII (ROC = 0.50). Conclusion Traditional models were inadequate to predict mortality of high-risk patients undergoing CABG. However, the HiriSCORE model was simple and accurate to predict mortality in high-risk patients.engopenAccesscardiac-surgeryeuroscore iisocietyvalidationoutcomesperformancemodelsimpactMortality risk prediction in high-risk patients undergoing coronary artery bypass grafting: Are traditional risk scores accurate?articleCopyright PUBLIC LIBRARY SCIENCE10.1371/journal.pone.0255662Multidisciplinary Sciences