Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPVICTOR, J. R.OLIVEIRA, L. M.LIRA, A. A. L.MUNIZ, B. P.DUARTE, A. J. S.SATO, M. N.2013-10-112013-10-112013PLACENTA, v.34, n.2, p.A17-A17, 20130143-4004https://observatorio.fm.usp.br/handle/OPI/3037Background: Previously we have been observed that pre-conceptional maternal immunization to OVA is able to prevent the development of allergy in mice. Methods: Female mice were immunized with OVA and mated with normal males. Offspring were evaluated at 3 days old (d.o.) or immunized with OVA and evaluated at 20 d.o. Results: Maternal immunization up-regulated the expression of FcγRIIb on offspring B cells at 3 and 20 d.o. Serum analysis revealed a down regulation on offspring IL-6 levels. Newborns show similar levels of TCD4+ cells producing IL-10, IL-17, IFN-γ or IL-4. Offspring from immune-mothers shows augmented IL-10+ and IL-17+ B cell levels. After offspring immunization we observed higher levels of IL-17+ and IFN-γ+ TCD4+ cells and IL-17+ and IFN-γ+ B cells of offspring from immune mothers. Conclusion: We confirmed the up-regulation of FcγRIIb on offspring B cells, and the augmented IL-10+ B cells on offspring suggest Breg cells involvement. The role of IL-17 must be investigated.engrestrictedAccessconferenceObjectCopyright W B SAUNDERS CO LTDDevelopmental BiologyObstetrics & GynecologyReproductive Biology