Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPNETO, Jose Cesar RosaCALDER, Philip C.CURI, RuiNEWSHOLME, PhilipSETHI, Jaswinder K.SILVEIRA, Loreana S.2021-10-202021-10-202021INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.16, article ID 8460, 16p, 2021https://observatorio.fm.usp.br/handle/OPI/42614Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.engopenAccessimmune cellslipidsfatty acidsmetabolismleukocytesmacrophageslymphocytesinflammationcytokinest-cell memorynf-kappa-bmetabolic-regulationperipheral-bloodglucose-metabolismppar-gammainflammationobeseactivationexpressionarticleCopyright MDPI10.3390/ijms22168460Biochemistry & Molecular BiologyChemistry, Multidisciplinary1422-0067