Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPALVARADO-MORA, Monica VivianaSANTANA, Rubia Anita FerrazSITNIK, RobertaFERREIRA, Paulo Roberto AbraoMANGUEIRA, Cristovao Luis PitangueiraCARRILHO, Flair JosePINHO, Joao Renato Rebello2017-11-272017-11-272011MEMORIAS DO INSTITUTO OSWALDO CRUZ, v.106, n.4, p.495-498, 20110074-0276https://observatorio.fm.usp.br/handle/OPI/23010The hepatitis B virus (HBV) is among the leading causes of chronic hepatitis, cirrhosis and hepatocellular carcinoma. In Brazil, genotype A is the most frequent, followed by genotypes D and F. Genotypes B and C are found in Brazil exclusively among Asian patients and their descendants. The aim of this study was to sequence the entire HBV genome of a Caucasian patient infected with HBV/C2 and to infer the origin of the virus based on sequencing analysis. The sequence of this Brazilian isolate was grouped with four other sequences described in China. The sequence of this patient is the first complete genome of HBV/C2 reported in Brazil.engopenAccesshepatitis B virusgenotype C2Chinabayesian analysescomplete genomeBrazilian patienthepatocellular-carcinomaphylogenetic relatednessgeographic-distributioncore promoterinfectionprecoremutantsamericachinaarticleCopyright FUNDACO OSWALDO CRUZParasitologyTropical Medicine