Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPFERNANDES, J. D.NICO, M. M. S.2023-12-042023-12-042023Fernandes, J. D.; Nico, M. M. S.. Aphthae. In: . Dermatology in Public Health Environments: A Comprehensive Textbook, Second Edition: SPRINGER INTERNATIONAL PUBLISHING, 2023. p.713-717.978-303113505-7; 978-303113504-0https://observatorio.fm.usp.br/handle/OPI/57186Aphthosis is an inflammatory disease characterized by painful, recurrent oral ulcerations. The cause of aphthosis is unknown, and several studies indicate a role of the immune system in the physiopathogenesis of this disease. Oral lesions mainly appear on the non-keratinized mucosa as painful, regular, round, or oval ulcers covered by a gray pseudomembrane and surrounded by an erythematous halo. The diagnosis of aphthosis is mainly established on clinical grounds. Treatment depends on the severity, recurrence rate, and response to previous therapies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.engrestrictedAccessAphthosisOral ulcersRecurrent aphthous stomatitisbookPartCopyright SPRINGER INTERNATIONAL PUBLISHING10.1007/978-3-031-13505-7_29