Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPV, Gabrielle de Oliveira S. NavarroFONSECA, LaisTALARICO, FernandaSPINDOLA, LeticiaSANTORO, Marcos L.OTA, Vanessa K.COGO-MOREIRA, HugoMARI, JairROHDE, Luis A.MIGUEL, Euripedes C.BRESSAN, Rodrigo A.PAN, Pedro M.GADELHA, AryI, Sintia Belangero2021-10-202021-10-202021JOURNAL OF PSYCHIATRIC RESEARCH, v.142, p.384-388, 20210022-3956https://observatorio.fm.usp.br/handle/OPI/42348Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.engrestrictedAccessPsychotic experiencesEnvironmentalPolygenic risk scorePolyenvironmental risk scorePERSPRSgeneral-populationsymptomsmetaanalysischildhoodcontinuumchildrenarticleCopyright PERGAMON-ELSEVIER SCIENCE LTD10.1016/j.jpsychires.2021.07.057Psychiatry1879-1379