Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPPEZATO, RogerioBALSALOBRE, LeonardoLIMA, MilenaBEZERRA, Thiago F. P.VOEGELS, Richard L.GREGORIO, Luis CarlosSTAMM, Aldo CassolZELE, Thibaut van2014-01-282014-01-282013JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, v.42, article ID 27, 5p, 20131916-0216https://observatorio.fm.usp.br/handle/OPI/4123This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.engopenAccessAirway remodelingSuperantigensNasal polypsgrowth-factor-betachronic rhinosinusitistgf-betamatrix metalloproteinasestissue inhibitorigeenterotoxinsexpressioncellsdifferentiationarticleCopyright BIOMED CENTRAL LTD10.1186/1916-0216-42-27Otorhinolaryngology