Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPLEANCA, Camila C.NUNES, Valeria S.PANZOLDO, Natalia B.ZAGO, Vanessa S.PARRA, Eliane S.CAZITA, Patricia M.JAUHIAINEN, MattiPASSARELLI, MarisaNAKANDAKARE, Edna R.FARIA, Eliana C. deQUINTAO, Eder C. R.2014-04-252014-04-252013CARDIOVASCULAR DIABETOLOGY, v.12, article ID 173, 7p, 20131475-2840https://observatorio.fm.usp.br/handle/OPI/5074Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.engopenAccessInsulin resistanceHDL-C concentrationLipoprotein lipasesLecithin cholesterol acyl transferasePre-beta1 HDLPlasma cholesterol metabolism markersCholesteryl ester transfer proteinPhospholipid transfer proteinhigh-density-lipoproteintransfer protein-activitytype-2 diabetes-mellitushepatic lipase activityintima-media thicknessnondiabetic subjectsester transferresistanceobesityacyltransferaseMetabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjectsarticleCopyright BIOMED CENTRAL LTD10.1186/1475-2840-12-173Cardiac & Cardiovascular SystemsEndocrinology & Metabolism