Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSPROMITI, RicardoHIRAYAMA, Andre Luis da SilvaARNONE, MarceloMAGALHAES, Renata Ferreira2022-08-122022-08-122022ANAIS BRASILEIROS DE DERMATOLOGIA, v.97, n.1, p.63-74, 20220365-0596https://observatorio.fm.usp.br/handle/OPI/48789Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences. (C) 2021 Sociedade Brasileira de Dermatologia.engopenAccessAcrodermatitisPsoriasisPsoriasis/epidemiologyPsoriasis/geneticsPsoriasis/physiopathologyPsoriasis/therapyimpetigo herpetiformischildhoodspectrumageparticleCopyright ELSEVIER SCIENCE INC10.1016/j.abd.2021.05.011Dermatology1806-4841